Biocatalysis, using enzymes for organic synthesis, has emerged as powerful tool for the
synthesis of active pharmaceutical ingredients (APIs). The first industrial biocatalytic …

Conventional methods for carrying out carbon–hydrogen functionalization and carbon–
nitrogen bond formation are typically conducted at elevated temperatures, and rely on …

The isoxazolidine ring represents one of the privileged structures in medicinal chemistry,
and there have been an increasing number of studies on isoxazolidine and isoxazolidine …

The cyclopentenone unit is a very powerful synthon for the synthesis of a variety of bioactive
target molecules. This is due to the broad diversity of chemical modifications available for …

Nucleoside analogues have proven to be highly successful chemotherapeutic agents in the
treatment of a wide variety of cancers. Several such compounds, including gemcitabine and …

This review summarizes recent literature (2000–2015) on the synthesis and pharmaceutical
properties of pyrrolopyrimidines. These modified pyrimidine bases, fused to a pyrrole ring …

Pyridine and pyrimidine derivatives have received great interest in recent pharmacological
research, being effective in the treatment of various malignancies, such as myeloid …

Highlights•Newly discovered enzymes possessing C-nucleoside synthase activity for
biocatalysis.•Multistep cascade reactions involving up to nine enzymes.•One-pot synthesis …

The increasing demand for the development of unprecedented routes to access fluorinated
molecules has led researchers to perform intriguing research around the world. In this …

Dipolar cycloaddition reactions of a sugar-based trifluoromethylated nitrone-to-maleimide
and allyl bromide afforded a series of cycloadducts in good yield. The same nitrone reacts …