Alzheimer's disease (AD) is the most common cause of dementia worldwide. As advancing
age is the greatest risk factor for developing AD, the number of those afflicted is expected to …

Amyloid-beta (Aβ) plays an important role in the pathogenesis of Alzheimer's disease.
Aberrant Aβ accumulation induces neuroinflammation, cerebrovascular alterations, and …

Beta amyloid is a protein fragment snipped from the amyloid precursor protein (APP).
Aggregation of these peptides into amyloid plaques is one of the hallmarks of Alzheimer's …

Formation of senile plaques composed of amyloid β peptide, a pathological hallmark of
Alzheimer disease, in human brains precedes disease onset by many years. Noninvasive …

One of the cardinal pathologic features of Alzheimer's disease (AD) is the formation of
senile, or amyloid, plaques. Transgenic mice have been developed that express one or …

Background Alzheimer's disease (AD) is characterized by a neurodegenerative progression
that alters cognition. On a phenotypical level, cognition is evaluated by means of the …

Amyloid plaques are one of the pathological hallmarks of Alzheimer's disease (AD). The
visualization of amyloid plaques in the brain is important to monitor AD progression and to …

Axonopathy is a pronounced attribute of many neurodegenerative diseases. In Alzheimer's
disease (AD), axonal swellings and degeneration are prevalent and may contribute to the …

The ability to detect individual Alzheimer's amyloid plaques in vivo by magnetic resonance
microimaging (MRI) should improve diagnosis and also accelerate discovery of effective …

Imaging modalities such as micro‐computed tomography (micro‐CT), micro‐positron
emission tomography (micro‐PET), high‐resolution MRI, optical imaging, and high …