The gut microbiome and hypertension

JA O'Donnell, T Zheng, G Meric… - Nature Reviews …, 2023 - nature.com
A large body of evidence has emerged in the past decade supporting a role for the gut
microbiome in the regulation of blood pressure. The field has moved from association to …

Gut microbiota and their metabolites in stroke: a double-edged sword

A Peh, JA O'Donnell, BRS Broughton, FZ Marques - Stroke, 2022 - Am Heart Assoc
Besides damaging the brain, stroke causes systemic changes, including to the
gastrointestinal system. A growing body of evidence supports the role of the gut and its …

The gut microbiome in hypertension: recent advances and future perspectives

EG Avery, H Bartolomaeus, A Maifeld, L Marko… - Circulation …, 2021 - Am Heart Assoc
The pathogenesis of hypertension is known to involve a diverse range of contributing factors
including genetic, environmental, hormonal, hemodynamic and inflammatory forces, to …

Lifestyle management of hypertension: International Society of Hypertension position paper endorsed by the World Hypertension League and European Society of …

FJ Charchar, PR Prestes, C Mills, SM Ching… - Journal of …, 2024 - journals.lww.com
Hypertension, defined as persistently elevated systolic blood pressure (SBP)> 140 mmHg
and/or diastolic blood pressure (DBP) at least 90 mmHg (International Society of …

Prebiotic intervention with HAMSAB in untreated essential hypertensive patients assessed in a phase II randomized trial

HA Jama, D Rhys-Jones, M Nakai, CK Yao… - Nature Cardiovascular …, 2023 - nature.com
Fibers remain undigested until they reach the colon, where some are fermented by gut
microbiota, producing metabolites called short-chain fatty acids (SCFAs), such as acetate …

[HTML][HTML] Commensal microbe-derived SCFA alleviates atrial fibrillation via GPR43/NLRP3 signaling

K Zuo, C Fang, Z Liu, Y Fu, Y Liu, L Liu… - … Journal of Biological …, 2022 - ncbi.nlm.nih.gov
Rationale: Dysbiotic gut microbiota (GM) and NLRP3 inflammasome are proarrhythmic
factors in atrial fibrillation (AF). Herein, whether short-chain fatty acid (SCFA) produced from …

The role of short-chain fatty acids of gut microbiota origin in hypertension

Y Wu, H Xu, X Tu, Z Gao - Frontiers in Microbiology, 2021 - frontiersin.org
Hypertension is a significant risk factor for cardiovascular and cerebrovascular diseases,
and its development involves multiple mechanisms. Gut microbiota has been reported to be …

Association of constipation with increased risk of hypertension and cardiovascular events in elderly Australian patients

CP Judkins, Y Wang, M Jelinic, A Bobik, A Vinh… - Scientific Reports, 2023 - nature.com
The association between constipation and cardiovascular risk is unclear. This population-
level matched cohort study compared the association of constipation with hypertension and …

How dietary fibre, acting via the gut microbiome, lowers blood pressure

C Xu, FZ Marques - Current Hypertension Reports, 2022 - Springer
Abstract Purpose of Review To discuss the interplay behind how a high-fibre diet leads to
lower blood pressure (BP) via the gut microbiome. Recent Findings Compelling evidence …

Essential hypertension is associated with changes in gut microbial metabolic pathways: a multisite analysis of ambulatory blood pressure

M Nakai, RV Ribeiro, BR Stevens, P Gill… - …, 2021 - Am Heart Assoc
Recent evidence supports a role for the gut microbiota in hypertension, but whether
ambulatory blood pressure is associated with gut microbiota and their metabolites remains …