Persistent infection with high-risk human papillomaviruses (HR-HPVs) is the causal factor in
over 99% of cervical cancer cases, and a significant proportion of oropharyngeal and …

An association between human papillomavirus (HPV) infection and the development of
cervical cancer was initially reported over 30 years ago, and today there is overwhelming …

Papillomaviruses induce benign and malignant epithelial tumors, and the viral E6
oncoprotein is essential for full transformation. E6 contributes to transformation by …

Papillomaviruses are small nonenveloped viruses with 55-nm-diameter icosahedral capsids
that contain double-stranded DNA genomes of approximately 8,000 bp. They are widely …

Infection with HPV starts with the access of the viral particles to basal cells in the epidermis,
potentially via microtraumas to the skin. The basal cells are able to keep away these …

Human papillomavirus (HPV) is the most common sexually transmitted infectious agent
worldwide, being also responsible for 5% of all human cancers. The integration and …

The papillomaviruses are small DNA viruses that encode approximately eight genes, and
require the host cell DNA replication machinery for their viral DNA replication. Thus …

Human papillomaviruses (HPVs), which are small, double-stranded, circular DNA viruses
infecting human epithelial cells, are associated with various benign and malignant lesions of …

The oncogenic potential of papillomaviruses (PVs) has been appreciated since the 1930s
yet the mechanisms of virally-mediated cellular transformation are still being revealed …

Dysfunction of p53 is observed in the many malignant tumors. In cervical cancer, p53 is
inactivated by degradation through the complex with human papilloma virus (HPV) …