Bone is a biomechanical tissue shaped by forces from muscles and gravitation.
Simultaneous bone and muscle decay and dysfunction (osteosarcopenia or sarco …

Bone is a remarkable tissue that can respond to external stimuli. The importance of
mechanical forces on the mass and structural development of bone has long been accepted …

Organisms rely on mechanosensing mechanisms to adapt to changes in their mechanical
environment. Fluid-filled network structures not only ensure efficient transport but can also …

Physical activity is essential to maintain skeletal mass and structure, but its effect seems to
diminish with age. To test the hypothesis that bone becomes less sensitive to mechanical …

Bone formation as well as bone healing capacity is known to be impaired in the elderly.
Although bone formation is outpaced by bone resorption in aged individuals, we hereby …

Bone is a tissue with enormous adaptive capacity, balancing resorption and formation
processes. It is known that mechanical loading shifts this balance towards an increased …

Dynamic processes modify bone micro-structure to adapt to external loading and avoid
mechanical failure. Age-related cortical bone loss is thought to occur because of increased …

This study investigates a comprehensive model of bone regeneration capacity of
dypiridamole-loaded 3D-printed bioceramic (DIPY-3DPBC) scaffolds composed of 100 …

Much is known about skeletal adaptation in relation to the mechanical functions that bones
serve. This includes how bone adapts to mechanical loading during an individual's lifetime …

In vivo, tibial loading in mice is increasingly used to study bone adaptation and
mechanotransduction. To achieve standardized and defined experimental conditions …