Amyloid-β precursor protein (APP) is a membrane-spanning protein with a large
extracellular domain and a much smaller intracellular domain. It is the source of the amyloid …

Lipid rafts and caveolae play a pivotal role in organization of signaling by TLR4 and several
other immune receptors. Beyond the simple cataloguing of signaling events …

Genetic association studies, in particular the genome-wide association study (GWAS)
design, have provided a wealth of novel insights into the aetiology of a wide range of human …

Phosphatidylcholine (PC) and phosphatidylethanolamine (PE) are major phospholipids in
mammalian membranes. In liver, PC is synthesized via the choline pathway or by …

Drug repurposing is potentially the fastest available option in the race to identify safe and
efficacious drugs that can be used to prevent and/or treat COVID‐19. By describing the life …

Assemblies of tau can transit between neurons, seeding aggregation in a prion-like manner.
To accomplish this, tau must cross cell-limiting membranes, a process that is poorly …

Niemann–Pick type C disease (NPCD) was first described in 1914 and affects approximately
1 in 150 000 live births. It is characterized clinically by diverse symptoms affecting liver …

Niemann-Pick type C1 (NPC1) disease is a fatal hereditary disorder characterized by a
defect in cholesterol trafficking and progressive neurodegeneration. Although the NPC1 …

Mammalian cells acquire most exogenous cholesterol through receptor‐mediated
endocytosis of low‐density lipoproteins (LDLs). After internalization, LDL cholesteryl esters …

Abstract Niemann–Pick type C1 (NPC1) disease is an autosomal recessive disorder
characterized clinically by neonatal jaundice, hepatosplenomegaly, vertical gaze palsy …