Testicular tumors are the most common tumors in adolescent and young men and germ cell
tumors (TGCTs) account for most of all testicular cancers. Increasing incidence of TGCTs …

Testicular cancer (TC) is the most common solid tumor among men aged between 15 and
40 years. TCs are highly aneuploid and the 12p isochromosome is the most frequent …

The mechanistic target of rapamycin (mTOR), via its two distinct multiprotein complexes,
mTORC1, and mTORC2, plays a central role in the regulation of cellular growth, metabolism …

Nonepithelial ovarian cancers (NEOC) are a group of rare malignancies, including germ cell
tumours (GCT) and sex cord-stromal tumours (SCST), along with small-cell carcinomas and …

Cancer cells are disordered by nature and thus featured by higher internal redox level than
healthy cells. Redox imbalance could trigger programmed cell death if exceeded a certain …

Testicular germ cell tumors (TGCTs) are a cancer pharmacology success story with a
majority of patients cured even in the highly advanced and metastatic setting. Successful …

Summary Background Germ cell tumors (GCTs) are highly curable diseases; however, not
all patients can be cured. Patients in their second relapse have especially poor prognoses …

Introduction Treatment options for patients with platinum refractory metastatic germ cell
tumours (GCT) relapsing after high-dose chemotherapy and autologous stem cell …

Ovarian germ cell tumors (GCTs) are rare in adults, but are more common in adolescents
and young adults. Contemporary management of ovarian GCTs is evolving as collaboration …

Testicular germ cell tumors (GCTs) are highly curable malignancies. Excellent survival rates
in patients with metastatic disease can be attributed to the exceptional sensitivity of GCTs to …