Over the years, several tumor biomarkers have been suggested to foresee the prognosis
oral squamous cell carcinoma (OSCC) patients. Here, we present a systematic review to …

Hypoxia-inducible factor 1 (HIF-1) regulates the transcription of many genes involved in key
aspects of cancer biology, including immortalization, maintenance of stem cell pools, cellular …

The central component of hypoxia sensing in the cell is the hypoxia-inducible factor (HIF)
transcriptional complex. HIF activity is deregulated in many human cancers, especially those …

Abstract Hypoxia-inducible factor-1 (HIF-1) plays important roles in regulating
radiosensitivity, making it a potentially promising target for tumour radiosensitisation. Here …

Advances in understanding of the molecular mechanisms underlying oral squamous cell
carcinoma (OSCC) have resulted in an increasing number of biomarkers that can be used to …

Hypoxia is an important feature of the microenvironment of a wide range of solid tumours. Its
critical role in radio-and chemoresistance and its significance as an adverse prognostic …

Cyclophilin A (CypA) has been reported to be overexpressed in cancer cells, especially in
solid tumors. To determine the role of CypA in tumorigenesis, we investigated the induction …

Hypoxia is a major event that occurs in most solid tumors. Intratumoral hypoxia is sufficient to
activate the key transcription factor, hypoxia-inducible factor (HIF) that mediates the …

The excessive and inappropriate production of reactive oxygen species (ROS) can cause
oxidative stress and is implicated in the pathogenesis of lung cancer. Cyclophilin A (CypA) …

Awareness increases that the tumor biology influences treatment outcome and prognosis in
cancer. Tumor hypoxia is thought to decrease sensitivity to radiotherapy and some forms of …