Silk chemistry and biomedical material designs

JK Sahoo, O Hasturk, T Falcucci… - Nature Reviews Chemistry, 2023 - nature.com
Silk fibroin has applications in different medical fields such as tissue engineering,
regenerative medicine, drug delivery and medical devices. Advances in silk chemistry and …

Silk fibroin as sustainable advanced material: material properties and characteristics, processing, and applications

A Reizabal, CM Costa, L Pérez‐Álvarez… - Advanced Functional …, 2023 - Wiley Online Library
Biobased resources are proposed as next‐generation materials for advanced application.
Among them, silk fibroin, a protein‐based material generally obtained from Bombyx mori …

Chemical modification of silk proteins: current status and future prospects

H Liu, Z Sun, C Guo - Advanced Fiber Materials, 2022 - Springer
Silk extracted from the cocoon of silkworm has been used as textile materials for thousands
of years. Recently, silk has been redefined as a protein-based biomaterial with great …

Multifunctional silk vinyl sulfone-based hydrogel scaffolds for dynamic material-cell interactions

T Falcucci, M Radke, JK Sahoo, O Hasturk, DL Kaplan - Biomaterials, 2023 - Elsevier
Biochemical and mechanical interactions between cells and the surrounding extracellular
matrix influence cell behavior and fate. Mimicking these features in vitro has prompted the …

Silk acid as an implantable biomaterial for tissue regeneration

Z Sun, R Huang, H Lyu, X Yu, W Wang… - Advanced …, 2023 - Wiley Online Library
Silk fibroin derived from the domesticated silkworm Bombyx mori is a protein‐based
biopolymer with low immunogenicity, intrinsic biodegradability, and tunable mechanical …

Modifying Naturally Occurring, Nonmammalian-Sourced Biopolymers for Biomedical Applications

BD Shirk, DL Heichel, LE Eccles… - ACS Biomaterials …, 2024 - ACS Publications
Natural biopolymers have a rich history, with many uses across the fields of healthcare and
medicine, including formulations for wound dressings, surgical implants, tissue culture …

Synthesis and characterization of silk ionomers for layer-by-layer electrostatic deposition on individual mammalian cells

O Hasturk, JK Sahoo, DL Kaplan - Biomacromolecules, 2020 - ACS Publications
Nanocoating of individual mammalian cells with polymer layers has been of increasing
interest in biotechnology and biomedical engineering applications. Electrostatic layer-by …

Silk bioconjugates: from chemistry and concept to application

SAL Matthew, FP Seib - ACS Biomaterials Science & Engineering, 2023 - ACS Publications
Medical silks have captured global interest. While silk sutures have a long track record in
humans, silk bioconjugates are still in preclinical development. This perspective examines …

Protein-based films as antifouling and drug-eluting antimicrobial coatings for medical implants

LS Wang, S Gopalakrishnan, DC Luther… - ACS applied materials …, 2021 - ACS Publications
Nosocomial infections, caused by bacterial contamination of medical devices and implants,
are a serious healthcare concern. We demonstrate here, the use of fluorous-cured protein …

Quantitative Functionalization of the Tyrosine Residues in Silk Fibroin through an Amino‐Tyrosine Intermediate

KG Hausken, RL Frevol, KP Dowdle… - Macromolecular …, 2022 - Wiley Online Library
Here, a reaction sequence that can be used to quantitatively modify the tyrosine residues in
silk protein from B. mori silkworms is demonstrated. A primary amine is installed ortho to the …