DNA damage is a key factor both in the evolution and treatment of cancer. Genomic
instability is a common feature of cancer cells, fuelling accumulation of oncogenic mutations …

Approximately 50% of all patients with cancer receive radiation therapy at some point during
the course of their treatment, and the majority of these patients are treated with curative …

Author links open overlay panel F. Cardoso a, A. Costa bc, L. Norton d, E. Senkus e, M.
Aapro f, F. André g, CH Barrios h, J. Bergh i, L. Biganzoli j, KL Blackwell k, MJ Cardoso l, T …

Radiotherapy and chemotherapy are effective treatment methods for many types of cancer,
but resistance is common. Recent findings indicate that antiviral type I interferon (IFN) …

DNA double-strand breaks are the critical lesions responsible for the majority of ionizing
radiation–induced cell killing. Thus, the ability of tumor cells to elicit a DNA damage …

Unique features of tumours that can be exploited by targeted therapies are a key focus of
current cancer research. One such approach is known as synthetic lethality screening, which …

PARP-1 is a critical enzyme in the repair of DNA strand breaks. Inhibition of PARP-1
increases the effectiveness of radiation in killing tumor cells. However, although the …

Utilizing the concept of synthetic lethality has provided new opportunities for the
development of targeted therapies, by allowing the targeting of loss of function genetic …

Purpose: While the addition of radiation to chemotherapy improves survival in patients with
locally advanced pancreatic cancer, more effective therapies are urgently needed. Thus, we …

Many conventional chemotherapeutic drugs exert their cytotoxic function by inducing DNA
damage in the tumor cell. Therefore, a cell-inherent DNA repair pathway, which reverses the …