Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities

M Bäck, A Yurdagul Jr, I Tabas, K Öörni… - Nature Reviews …, 2019 - nature.com
Atherosclerosis is a lipid-driven inflammatory disease of the arterial intima in which the
balance of pro-inflammatory and inflammation-resolving mechanisms dictates the final …

Lipoxin and resolvin receptors transducing the resolution of inflammation in cardiovascular disease

J Pirault, M Bäck - Frontiers in Pharmacology, 2018 - frontiersin.org
A non-resolving inflammation results in a chronic inflammatory response, characteristic of
atherosclerosis, abdominal aortic aneurysms and several other cardiovascular diseases …

Polyunsaturated fatty acids: conversion to lipid mediators, roles in inflammatory diseases and dietary sources

JL Harwood - International Journal of Molecular Sciences, 2023 - mdpi.com
Polyunsaturated fatty acids (PUFAs) are important components of the diet of mammals. Their
role was first established when the essential fatty acids (EFAs) linoleic acid and α-linolenic …

A novel anti-inflammatory role of omega-3 PUFAs in prevention and treatment of atherosclerosis and vascular cognitive impairment and dementia

M Simonetto, M Infante, RL Sacco, T Rundek… - Nutrients, 2019 - mdpi.com
Atherosclerosis is an inflammatory chronic disease affecting arterial vessels and leading to
vascular diseases, such as stroke and myocardial infarction. The relationship between …

[HTML][HTML] Perivascular adipose tissue–derived extracellular vesicle miR-221-3p mediates vascular remodeling

X Li, LL Ballantyne, Y Yu, CD Funk - The FASEB Journal, 2019 - ncbi.nlm.nih.gov
Adipose tissue–secreted extracellular vesicles (EVs) containing microRNAs (miRNAs)
convey intercellular message signaling. The biogenesis of EV-miRNAs from perivascular …

The resolution of inflammation through omega-3 fatty acids in atherosclerosis, intimal hyperplasia, and vascular calcification

M Carracedo, G Artiach, H Arnardottir… - Seminars in …, 2019 - Springer
Omega-3 fatty acids serve as the substrate for the formation of a group of lipid mediators that
mediate the resolution of inflammation. The cardiovascular inflammatory response in …

Pharmacological prevention of intimal hyperplasia: a state-of-the-art review

T Melnik, O Jordan, JM Corpataux, F Delie… - Pharmacology & …, 2022 - Elsevier
Intimal hyperplasia (IH) occurs in a considerable number of cases of blood vessel
reconstruction by stenting or balloon angioplasty, venous bypass grafting, and arteriovenous …

[HTML][HTML] Regression of human coronary artery plaque is associated with a high ratio of (18-hydroxy-eicosapentaenoic acid+ resolvin E1) to leukotriene B4

FK Welty, F Schulte, A Alfaddagh… - … : official publication of …, 2021 - ncbi.nlm.nih.gov
Inflammation in arterial walls leads to coronary artery disease (CAD). We previously
reported that a high omega-3 fatty index was associated with prevention of progression of …

Resolvin D2 attenuates cardiovascular damage in angiotensin II-induced hypertension

LS Díaz del Campo, AB García-Redondo… - …, 2023 - Am Heart Assoc
Background: Resolution of inflammation is orchestrated by specialized proresolving lipid
mediators (SPMs), and this would be impaired in some cardiovascular diseases. Among …

Omega‐3 fatty acids, cardiovascular risk, and the resolution of inflammation

M Bäck, GK Hansson - The FASEB journal, 2019 - Wiley Online Library
Although a high marine food intake is considered cardioprotective, randomized trials of ω‐3
fatty acids initially generated conflicting results in terms of the role of ω‐3 supplementation in …