The aim of the present study was to develop and evaluate a novel drug solubilization
platform (so-called solid nanodispersion) prepared by a simple co-grinding and solvent-free …

Results: Insulin nanomedicines based on alginate-dextran sulfate core with a chitosan-
polyethylene glycol-albumin shell reduced glycaemia in a dose dependent manner. Orally …

Epigallocatechin gallate (EGCG) declares massive health benefits, while poor oral
absorption and susceptibility to oxidation and degradation constrained clinical applications …

The purpose of this investigation was to develop an exploratory two-step level A IVIVC for
three telmisartan oral immediate release formulations, the reference product Micardis, and …

Sodium dodecyl sulfate (SDS) is generally regarded as a potent permeability enhancer in
oral formulations; however, one concern related to the use of any permeation enhancer is its …

BCS III drugs exhibit high solubility and low permeability, and some excipients were
reported to increase their permeability. Although some permeability-enhancing excipients …

The purpose of this work is to investigate the discriminatory power of the Biopharmaceutics
Classification System (BCS)-biowaiver in vitro methodology, ie, to investigate if a BCS …

This work aimed to evaluate the applicability of rhamnolipids as permeation enhancers for
oral drugs. In this study, rhamnolipids were found to effectively increase the paracellular and …

Intestinal permeability is a key biopharmaceutical variable in pharmaceutical research and
development, and regulatory assessment. In situ rat models are often used to predict the …

The gastrointestinal (GI) tract is one of the most popular and used routes of drug product
administration due to the convenience for better patient compliance and reduced costs to the …