Severe acute respiratory syndrome coronaviruses 2 (SARS-CoV-2) causing coronavirus
disease 2019 (COVID-19) affected the health of human beings and the global economy. The …

The term “undruggable” refers to proteins or other biological targets that have been
historically challenging to target with conventional drugs or therapeutic strategies because …

The development of the sulfur (VI)–fluoride exchange (SuFEx) and modular diazotransfer
(MoDAT) reactions represent important milestones in the evolution of click chemistry …

Specifically improving the intratumoral accumulation and retention and achieving the
maximum therapeutic efficacy of small-molecule chemotherapeutics remains a considerable …

In nature, DNA phosphorothioate (PT) is found in the genomic materials of some
prokaryotes. In contrast, whether there is natural RNA PT is still a question under debate. A …

Aptamers are oligonucleotides with antibody-like binding function, selected from large
combinatorial libraries. In this study, we modified a DNA aptamer library with N …

Covalent inhibitors provide persistent inhibition while maintaining excellent selectivity and
efficacy by creating stable covalent connections with specific amino acids in target proteins …

Aza‐S (VI) fluorides are crucial compounds in the synthesis of various S (VI) derivatives,
which find broad applications in drug discovery. However, the synthesis of sulfonimidoyl and …

A covalent binder for a target protein was obtained by a direct single-round screening of a
latent-warhead-modified DNA library via affinity/reactivity-based co-selection of aptameric …

Sulfur (VI) fluoride exchange (SuFEx), a new generation of click chemistry, enables the
creation of a stable covalent linkage between a protein and its interacting biomolecule. This …