FAK in cancer: from mechanisms to therapeutic strategies

HH Chuang, YY Zhen, YC Tsai, CH Chuang… - International journal of …, 2022 - mdpi.com
Focal adhesion kinase (FAK), a non-receptor tyrosine kinase, is overexpressed and
activated in many cancer types. FAK regulates diverse cellular processes, including growth …

FAK in cancer: mechanistic findings and clinical applications

FJ Sulzmaier, C Jean, DD Schlaepfer - Nature reviews cancer, 2014 - nature.com
Focal adhesion kinase (FAK) is a cytoplasmic protein tyrosine kinase that is overexpressed
and activated in several advanced-stage solid cancers. FAK promotes tumour progression …

Protein interactions at endothelial junctions and signaling mechanisms regulating endothelial permeability

YA Komarova, K Kruse, D Mehta, AB Malik - Circulation research, 2017 - Am Heart Assoc
The monolayer of endothelial cells lining the vessel wall forms a semipermeable barrier (in
all tissue except the relatively impermeable blood–brain and inner retinal barriers) that …

Passing the vascular barrier: endothelial signaling processes controlling extravasation

N Wettschureck, B Strilic… - Physiological …, 2019 - journals.physiology.org
A central function of the vascular endothelium is to serve as a barrier between the blood and
the surrounding tissue of the body. At the same time, solutes and cells have to pass the …

Mind the gap: mechanisms regulating the endothelial barrier

MY Radeva, J Waschke - Acta physiologica, 2018 - Wiley Online Library
The endothelial barrier consists of intercellular contacts localized in the cleft between
endothelial cells, which is covered by the glycocalyx in a sievelike manner. Both types of …

Mechanisms regulating endothelial permeability

S Sukriti, M Tauseef, P Yazbeck… - Pulmonary …, 2014 - journals.sagepub.com
The endothelial monolayer partitioning underlying tissue from blood components in the
vessel wall maintains tissue fluid balance and host defense through dynamically opening …

The pulmonary endothelium in acute respiratory distress syndrome: insights and therapeutic opportunities

FR Millar, C Summers, MJ Griffiths, MR Toshner… - Thorax, 2016 - thorax.bmj.com
The pulmonary endothelium is a dynamic, metabolically active layer of squamous
endothelial cells ideally placed to mediate key processes involved in lung homoeostasis …

Understanding the roles of FAK in cancer: inhibitors, genetic models, and new insights

H Yoon, JP Dehart, JM Murphy… - … of Histochemistry & …, 2015 - journals.sagepub.com
Focal adhesion kinase (FAK) is a protein tyrosine kinase that regulates cellular adhesion,
motility, proliferation and survival in various types of cells. Interestingly, FAK is activated …

Role of epithelial sodium channels in the regulation of lung fluid homeostasis

S Matalon, R Bartoszewski… - American Journal of …, 2015 - journals.physiology.org
In utero, fetal lung epithelial cells actively secrete Cl− ions into the lung air spaces while Na+
ions follow passively to maintain electroneutrality. This process, driven by an …

[HTML][HTML] Tyrosine-protein kinase Yes controls endothelial junctional plasticity and barrier integrity by regulating VE-cadherin phosphorylation and endocytosis

Y Jin, Y Ding, M Richards, M Kaakinen… - Nature Cardiovascular …, 2022 - nature.com
Vascular endothelial (VE)-cadherin in endothelial adherens junctions is an essential
component of the vascular barrier, critical for tissue homeostasis and implicated in diseases …