Objective To evaluate the application of RNAscope in the clinical diagnostic field compared
to the current 'gold standard'methods employed for testing gene expression levels, including …

The ability to quantify DNA, RNA, and protein variations at the single cell level has
revolutionized our understanding of cellular heterogeneity within tissues. Via such analyses …

Understanding of the molecular drivers of lineage diversification and tissue patterning
during primary germ layer development requires in-depth knowledge of the dynamic …

Dysfunction of gamma-aminobutyric acid (GABA) ergic circuits is strongly associated with
neurodevelopmental disorders. However, it is unclear how genetic predispositions impact …

RNA-based therapeutics are highly promising for the treatment of numerous diseases, by
their ability to tackle the genetic origin in multiple possible ways. RNA molecules are …

Background: The human cochlea was earlier believed to lack capacity to mount specific
immune responses. Recent studies established that the human cochlea holds …

As gene therapy enters mainstream medicine, it is more important than ever to have a grasp
of exactly how to leverage it for maximum benefit. The development of new targeting …

Skeletal muscle myofibers are large syncytial cells comprising hundreds of myonuclei, and
in situ hybridization experiments have reported a range of transcript localization patterns …

Abstract Background The Ca2+/calmodulin-dependent protein kinase kinases (CaMKKs)
are serine/threonine-directed protein kinases that are activated following increases in …

Highly multiplexed protein and RNA in situ detection on a single tissue section concurrently
is highly desirable for both basic and applied biomedical research. CO-detection by …