Ever since the first isolation of Exaltolide 1 (Figure 1) in 1927 by Kerschbaum, 1 interest in
macrocyclic lactones, defined as lactones with more than 8 atoms in the ring, has been …

Macrocyclic scaffolds are commonly found in bioactive natural products and pharmaceutical
molecules. So far, a large number of macrocyclic natural products have been isolated and …

Nature presents us countless numbers of natural products with complex and fascinating
structures and useful properties. Macrodiolides belong to one relatively small but interesting …

The main objective of this review is to provide a comprehensive survey of methods used for
stereoselective construction of carbon–nitrogen bonds during the total synthesis of nitrogen …

Although radicals are usually viewed as neutral, relatively nonpolar species, polar effects in
radical chemistry are wellknown 1 and continue to be exploited in organic synthesis. 2 For …

1. INTRODUCTION Ever since the first isolation of Exaltolide 1 (Figure 1) in 1927 by
Kerschbaum, 1 interest in macrocyclic lactones, defined as lactones with more than 8 atoms …

Abstract The Hosomi-Sakurai allylation is the Lewis acid-promoted carbonyl allylation with
nucleophilic allylsilanes. Since its discovery in 1976, this highly useful transformation has …

The proposed structure of lasonolide A was synthesized employing radical cyclization
reactions of β-alkoxyacrylates for preparation of the tetrahydropyranyl units A and B, but the …

Total synthesis of the unnatural (−)-enantiomer of lasonolide A was achieved starting from
ethyl l-malate. The two tetrahydropyranyl fragments were prepared stereoselectively via …

An efficient, broadly applicable, operationally simple, and divergent process for the
transformation of imides into a range of carboxylic acid derivatives under mild conditions is …