Mode of action-based risk assessment of genotoxic carcinogens

A Hartwig, M Arand, B Epe, S Guth, G Jahnke… - Archives of …, 2020 - Springer
The risk assessment of chemical carcinogens is one major task in toxicology. Even though
exposure has been mitigated effectively during the last decades, low levels of carcinogenic …

Hormesis: The dose response for the 21st century: The future has arrived

E Agathokleous, EJ Calabrese - Toxicology, 2019 - Elsevier
Dose-response is the backbone of toxicology, and one of the most debated scientific issues
over the 20 th century. It was in the last century that the scientific community applauded the …

A global environmental health perspective and optimisation of stress

E Agathokleous, EJ Calabrese - Science of the Total Environment, 2020 - Elsevier
The phrase “what doesn't kill us makes us stronger” suggests the possibility that living
systems have evolved a spectrum of adaptive mechanisms resulting in a biological stress …

Effect of microplastics on aquatic biota: A hormetic perspective

T Sun, J Zhan, F Li, C Ji, H Wu - Environmental Pollution, 2021 - Elsevier
As emerging pollutants, microplastics (MPs) have been found globally in various freshwater
and marine matrices. This study recompiled 270 endpoints of 3765 individuals from 43 …

Environmental hormesis in living systems: The role of hormetic trade-offs

EA Erofeeva - Science of the Total Environment, 2023 - Elsevier
Hormesis (low-dose stimulation and high-dose inhibition) can be accompanied by hormetic
trade-offs, that is, stimulation of some traits and inhibition (trade-off 1) or invariability (trade …

Hormesis induced by silver iodide, hydrocarbons, microplastics, pesticides, and pharmaceuticals: Implications for agroforestry ecosystems health

E Agathokleous, D Barceló, J Rinklebe, C Sonne… - Science of The Total …, 2022 - Elsevier
Increasing amounts of silver iodide (AgI) in the environment are expected because of the
recent massive expansion of weather modification programs. Concurrently …

Low-dose ionizing radiation as a hormetin: experimental observations and therapeutic perspective for age-related disorders

A Vaiserman, JM Cuttler, Y Socol - Biogerontology, 2021 - Springer
Hormesis is any kind of biphasic dose-response when low doses of some agents are
beneficial while higher doses are detrimental. Radiation hormesis is the most thoroughly …

Ecotoxicological effects of decommissioning offshore petroleum infrastructure: A systematic review

A MacIntosh, K Dafforn, B Penrose… - Critical Reviews in …, 2022 - Taylor & Francis
Successful decommissioning of subsea oil and gas infrastructure requires a safe and
effective approach to assess and manage waste products. These products, often present as …

Hormesis in the heavy metal accumulator plant Tillandsia ionantha under Cd exposure: Frequency and function of different biomarkers

J Zhang, Z Tang, E Agathokleous, G Zheng… - Science of The Total …, 2023 - Elsevier
Cadmium is one of the most biotoxic substances among all heavy metals, but an increasing
number of studies indicate that low-dose Cd can induce hormesis in some plants. However …

[HTML][HTML] The LNT model for cancer induction is not supported by radiobiological data

BR Scott, S Tharmalingam - Chemico-biological interactions, 2019 - Elsevier
The hallmarks of cancer have been the focus of much research and have influenced the
development of risk models for radiation-induced cancer. However, natural defenses against …