Post-translational modifications, such as phosphorylation, ubiquitination and acetylation,
play crucial roles in the regulation of autophagy. Acetylation has emerged as an important …

Autophagy is a catabolic process for unnecessary or dysfunctional cytoplasmic contents by
lysosomal degradation pathways. Autophagy is implicated in various biological processes …

Beclin 1 is the first mammalian autophagy protein identified as a novel Bcl-2-interacting
protein. Subsequent studies have demonstrated that this landmark protein is essential for …

Macroautophagy is a conserved catabolic process observed in all eukaryotic cells, during
which selected cellular components are transported to and broken down within lysosomes …

Autophagy is the process of cellular self-eating by a double-membrane organelle, the
autophagosome. A range of signaling processes converge on two protein complexes to …

Autophagy is the major cellular pathway to degrade dysfunctional organelles and protein
aggregates. Autophagy is particularly important in neurons, which are terminally …

Autophagy is a lysosomal degradation process and protective housekeeping mechanism to
eliminate damaged organelles, long-lived misfolded proteins and invading pathogens …

Autophagy is a process of self-degradation that enables the cell to survive when faced with
starvation or stressful conditions. The mechanistic target of rapamycin (mTOR), also known …

Over the past two decades, the molecular machinery that underlies autophagic responses
has been characterized with ever increasing precision in multiple model organisms …

Significance: Autophagy is a highly conserved eukaryotic cellular recycling process.
Through the degradation of cytoplasmic organelles, proteins, and macromolecules, and the …