Methylation of DNA and of histone 3 at Lys 9 (H3K9) are highly correlated with gene
silencing in eukaryotes from fungi to humans. Both of these epigenetic marks need to be …

Secondary metabolite biosynthesis genes in fungi are usually physically linked and
organized in large gene clusters. The physical linkage of genes involved in the same …

Genomic plasticity enables adaptation to changing environments, which is especially
relevant for pathogens that engage in “arms races” with their hosts. In many pathogens …

Repetitive elements (REs) compose∼ 50% of the human genome and are normally
transcriptionally silenced, although the mechanism has remained elusive. Through an RNAi …

Plant pathogens secrete an arsenal of small secreted proteins (SSPs) acting as effectors that
modulate host immunity to facilitate infection. SSP-encoding genes are often located in …

Histone-modifying enzymes are responsible for regulating transcription, recombination, DNA
repair, DNA replication, chromatid cohesion, and chromosome segregation. Fungi are …

The filamentous fungus Neurospora crassa has provided a rich source of knowledge on
epigenetic phenomena that would have been difficult or impossible to gain from other …

Methylated lysine 27 on histone H3 (H3K27me) marks repressed “facultative
heterochromatin,” including developmentally regulated genes in plants and animals. The …

Cytosine methylation of DNA is a widespread modification of DNA that plays numerous
critical roles. In the yeast Cryptococcus neoformans, CG methylation occurs in transposon …

Comparative genomics has recently provided unprecedented insights into the biology and
evolution of the fungal lineage. In the postgenomics era, a major research interest focuses …