Lipid droplets in neurodegenerative disorders

BC Farmer, AE Walsh, JC Kluemper… - Frontiers in …, 2020 - frontiersin.org
Knowledge of lipid droplets (LDs) has evolved from simple depots of lipid storage to
dynamic and functionally active organelles involved in a variety of cellular functions. Studies …

Regulation of type I interferon responses

LB Ivashkiv, LT Donlin - Nature Reviews Immunology, 2014 - nature.com
Type I interferons (IFNs) activate intracellular antimicrobial programmes and influence the
development of innate and adaptive immune responses. Canonical type I IFN signalling …

Expanding roles for lipid droplets

MA Welte - Current biology, 2015 - cell.com
Lipid droplets are the intracellular sites for neutral lipid storage. They are critical for lipid
metabolism and energy homeostasis, and their dysfunction has been linked to many …

Lipid bodies containing oxidatively truncated lipids block antigen cross-presentation by dendritic cells in cancer

F Veglia, VA Tyurin, D Mohammadyani, M Blasi… - Nature …, 2017 - nature.com
Cross-presentation is a critical function of dendritic cells (DCs) required for induction of
antitumor immune responses and success of cancer immunotherapy. It is established that …

Biogenesis of the multifunctional lipid droplet: lipids, proteins, and sites

A Pol, SP Gross, RG Parton - Journal of Cell Biology, 2014 - rupress.org
Lipid droplets (LDs) are ubiquitous dynamic organelles that store and supply lipids in all
eukaryotic and some prokaryotic cells for energy metabolism, membrane synthesis, and …

Revealing the Viscosity Changes in Lipid Droplets during Ferroptosis by the Real-Time and In Situ Near-Infrared Imaging

B Dong, W Song, Y Lu, Y Sun, W Lin - Acs Sensors, 2020 - ACS Publications
Ferroptosis is characterized by the massive lipid peroxidation, and recently has been
demonstrated to be closely associated with lipid droplets (LDs). However, the changes of …

A near-infrared probe for specific imaging of lipid droplets in living cells

X Wu, X Wang, Y Li, F Kong, K Xu, L Li… - Analytical …, 2022 - ACS Publications
Lipid droplets (LDs) are involved in various physiological processes and associated with
cancer development, and are regarded as a potential tumor marker for cancer diagnosis …

Lipid droplet formation in Mycobacterium tuberculosis infected macrophages requires IFN-γ/HIF-1α signaling and supports host defense

M Knight, J Braverman, K Asfaha, K Gronert… - PLoS …, 2018 - journals.plos.org
Lipid droplet (LD) formation occurs during infection of macrophages with numerous
intracellular pathogens, including Mycobacterium tuberculosis. It is believed that M …

The lipid droplet—a well-connected organelle

Q Gao, JM Goodman - Frontiers in cell and developmental biology, 2015 - frontiersin.org
Our knowledge of inter-organellar communication has grown exponentially in recent years.
This review focuses on the interactions that cytoplasmic lipid droplets have with other …

Immunometabolism in the development of rheumatoid arthritis

CM Weyand, JJ Goronzy - Immunological reviews, 2020 - Wiley Online Library
In rheumatoid arthritis (RA), breakdown of self‐tolerance and onset of clinical disease are
separated in time and space, supporting a multi‐hit model in which emergence of …