Skeletal infections: microbial pathogenesis, immunity and clinical management

EA Masters, BF Ricciardi, KLM Bentley… - Nature Reviews …, 2022 - nature.com
Osteomyelitis remains one of the greatest risks in orthopaedic surgery. Although many
organisms are linked to skeletal infections, Staphylococcus aureus remains the most …

Evolving concepts in bone infection: redefining “biofilm”,“acute vs. chronic osteomyelitis”,“the immune proteome” and “local antibiotic therapy”

EA Masters, RP Trombetta, KL de Mesy Bentley… - Bone research, 2019 - nature.com
Osteomyelitis is a devastating disease caused by microbial infection of bone. While the
frequency of infection following elective orthopedic surgery is low, rates of reinfection are …

Staphylococcus aureus Vaccine Research and Development: The Past, Present and Future, Including Novel Therapeutic Strategies

J Clegg, E Soldaini, RM McLoughlin… - Frontiers in …, 2021 - frontiersin.org
Staphylococcus aureus is one of the most important human pathogens worldwide. Its high
antibiotic resistance profile reinforces the need for new interventions like vaccines in …

Development of a vaccine against Staphylococcus aureus invasive infections: Evidence based on human immunity, genetics and bacterial evasion mechanisms

LS Miller, VG Fowler Jr, SK Shukla… - FEMS microbiology …, 2020 - academic.oup.com
Invasive Staphylococcus aureus infections are a leading cause of morbidity and mortality in
both hospital and community settings, especially with the widespread emergence of virulent …

Mechanisms of Immune Evasion and Bone Tissue Colonization That Make Staphylococcus aureus the Primary Pathogen in Osteomyelitis

G Muthukrishnan, EA Masters, JL Daiss… - Current osteoporosis …, 2019 - Springer
Abstract Purpose of Review Staphylococcus aureus is the primary pathogen responsible for
osteomyelitis, which remains a major healthcare burden. To understand its dominance, here …

Staphylococcus aureus Evasion of Host Immunity in the Setting of Prosthetic Joint Infection: Biofilm and Beyond

BF Ricciardi, G Muthukrishnan, E Masters… - Current reviews in …, 2018 - Springer
Abstract Purpose of Review The incidence of complications from prosthetic joint infection
(PJI) is increasing, and treatment failure remains high. We review the current literature with a …

Orthopaedic device-related infection: current and future interventions for improved prevention and treatment

TF Moriarty, R Kuehl, T Coenye… - EFORT open …, 2016 - eor.bioscientifica.com
Orthopaedic and trauma device-related infection (ODRI) remains one of the major
complications in modern trauma and orthopaedic surgery. Despite best practice in medical …

[HTML][HTML] Current concepts of osteomyelitis: from pathologic mechanisms to advanced research methods

MI Hofstee, G Muthukrishnan, GJ Atkins, M Riool… - The American journal of …, 2020 - Elsevier
Osteomyelitis is an inflammation of the bone and bone marrow that is most commonly
caused by a Staphylococcus aureus infection. Much of our understanding of the underlying …

Diagnostic challenges and future perspectives in fracture-related infection

M Morgenstern, R Kühl, H Eckardt, Y Acklin, B Stanic… - Injury, 2018 - Elsevier
Fracture-related infection (FRI) is one of the most challenging complications in orthopaedic
trauma surgery. It has severe consequences for patients and an important socio-economic …

Fighting Staphylococcus aureus biofilms with monoclonal antibodies

D Raafat, M Otto, K Reppschläger, J Iqbal… - Trends in …, 2019 - cell.com
Staphylococcus aureus (S. aureus) is a notorious pathogen and one of the most frequent
causes of biofilm-related infections. The treatment of S. aureus biofilms is hampered by the …