The impact of targeted therapies and immunotherapy in melanoma brain metastases: A systematic review and meta‐analysis
Background Targeted therapies (TT), combination immunotherapy (CMI), and
monoimmunotherapy (MI) in combination with radiotherapy (CRI) or not are commonly used …
monoimmunotherapy (MI) in combination with radiotherapy (CRI) or not are commonly used …
Melanoma brain metastasis: mechanisms, models, and medicine
DA Kircher, MR Silvis, JH Cho, SL Holmen - International journal of …, 2016 - mdpi.com
The development of brain metastases in patients with advanced stage melanoma is
common, but the molecular mechanisms responsible for their development are poorly …
common, but the molecular mechanisms responsible for their development are poorly …
[HTML][HTML] Vemurafenib in metastatic melanoma patients with brain metastases: an open-label, single-arm, phase 2, multicentre study
GA McArthur, M Maio, A Arance, P Nathan, C Blank… - Annals of …, 2017 - Elsevier
Background Vemurafenib has shown activity in patients withBRAF V600 mutated melanoma
with brain metastases (BM). This phase 2 study evaluated vemurafenib in patients …
with brain metastases (BM). This phase 2 study evaluated vemurafenib in patients …
Intratumoral CD40 activation and checkpoint blockade induces T cell-mediated eradication of melanoma in the brain
CD40 agonists bind the CD40 molecule on antigen-presenting cells and activate them to
prime tumor-specific CD8+ T cell responses. Here, we study the antitumor activity and …
prime tumor-specific CD8+ T cell responses. Here, we study the antitumor activity and …
Intracranial antitumor activity with encorafenib plus binimetinib in patients with melanoma brain metastases: a case series
K Holbrook, J Lutzky, MA Davies, JM Davis, IC Glitza… - Cancer, 2020 - Wiley Online Library
Background Sixty percent of patients with stage IV melanoma may develop brain
metastases, which result in significantly increased morbidity and a poor overall prognosis …
metastases, which result in significantly increased morbidity and a poor overall prognosis …
[HTML][HTML] Survival of melanoma patients treated with targeted therapy and immunotherapy after systematic upfront control of brain metastases by radiosurgery
C Gaudy-Marqueste, AS Dussouil, R Carron… - European Journal of …, 2017 - Elsevier
Background Targeted therapy (TT) and immunotherapies (ITs) have dramatically improved
survival in metastatic melanoma (MM). However, their efficacy on brain metastasis (BM) …
survival in metastatic melanoma (MM). However, their efficacy on brain metastasis (BM) …
Immune checkpoint inhibitor therapy may increase the incidence of treatment-related necrosis after stereotactic radiosurgery for brain metastases: a systematic review …
Objectives To compare the incidence of treatment-related necrosis between combination
SRS+ ICI therapy and SRS therapy alone in patients with brain metastases from melanoma …
SRS+ ICI therapy and SRS therapy alone in patients with brain metastases from melanoma …
Upfront surgical resection of melanoma brain metastases provides a bridge toward immunotherapy‐mediated systemic control
C Alvarez‐Breckenridge, A Giobbie‐Hurder… - The …, 2019 - academic.oup.com
Background Immune checkpoint blockade has systemic efficacy in patients with metastatic
melanoma, including those with brain metastases (MBMs). However, immunotherapy …
melanoma, including those with brain metastases (MBMs). However, immunotherapy …
Treatment options for recurrent high-grade gliomas
HS Birk, SJ Han, NA Butowski - CNS oncology, 2017 - Taylor & Francis
High-grade gliomas are aggressive brain tumors encompassing Grade III and IV
classifications. Of these, glioblastoma (GB) is the most malignant with a high rate of …
classifications. Of these, glioblastoma (GB) is the most malignant with a high rate of …
Automated detection and segmentation of brain metastases in malignant melanoma: evaluation of a dedicated deep learning model
L Pennig, R Shahzad, L Caldeira… - American Journal …, 2021 - Am Soc Neuroradiology
BACKGROUND AND PURPOSE: Malignant melanoma is an aggressive skin cancer in
which brain metastases are common. Our aim was to establish and evaluate a deep …
which brain metastases are common. Our aim was to establish and evaluate a deep …