Transformative technologies are enabling the construction of three-dimensional maps of
tissues with unprecedented spatial and molecular resolution. Over the next seven years, the …

Metabolic heterogeneity of cancer contributes significantly to its poor treatment outcomes
and prognosis. As a result, studies continue to focus on identifying new biomarkers and …

Spatial metabolomics can reveal intercellular heterogeneity and tissue organization. Here
we report on the spatial single nuclear metabolomics (SEAM) method, a flexible platform …

Imaging of proteoforms in human tissues is hindered by low molecular specificity and limited
proteome coverage. Here, we introduce proteoform imaging mass spectrometry (PiMS) …

Mass spectrometry imaging (MSI) enables label-free spatial mapping of hundreds of
biomolecules in tissue sections. This capability provides valuable information on tissue …

Mass spectrometry imaging (MSI) combines molecular and spatial information in a valuable
tool for a wide range of applications. Matrix‐assisted laser desorption/ionization (MALDI) is …

Endogenous small molecules play important roles in biological processes and are closely
related to the occurrence and development of many diseases. Profiling of spatial distribution …

Desorption electrospray ionization mass spectrometry imaging (DESI‐MSI) is one of the
least specimen destructive ambient ionization mass spectrometry tissue imaging methods. It …

Tissue analysis, which is essential to histology and is considered the benchmark for the
diagnosis and prognosis of many illnesses, including cancer, is significant. During surgery …

Nanospray desorption electrospray mass spectrometry imaging (nano-DESI MSI) enables
quantitative mapping of hundreds of molecules in biological samples with minimal sample …