Gram-positive bacteria use sortase cysteine transpeptidase enzymes to covalently attach
proteins to their cell wall and to assemble pili. In pathogenic bacteria sortases are potential …

Bacteria possess complex and varying cell walls with many surface exposed proteins.
Sortases are responsible for the covalent attachment of specific proteins to the …

Bioorthogonal, chemoselective ligation methods are an essential part of the tools utilized to
investigate biochemical pathways. Specifically enzymatic approaches are valuable methods …

The bacterial cell wall contains numerous surface-exposed proteins, which are covalently
anchored and assembled by a sortase family of transpeptidase enzymes. The sortase are …

The fabrication of novel biomaterial scaffolds with improved biological interactions and
mechanical properties is an important aspect of tissue engineering. The three-dimensional …

Sortase A (SrtA) anchors surface proteins to the cell wall and aids biofilm formation during
infection, which functions as a key virulence factor of important Gram-positive pathogens …

Sortases are cysteine transpeptidases that assemble surface proteins and pili in their cell
envelope. Encoded by all Gram-positive bacteria, few Gram-negative bacteria and archaea …

Dehaloperoxidase (DHP) is a multifunctional hemeprotein with a functional switch generally
regulated by the chemical class of the substrate. Its two isoforms, DHP-A and DHP-B, differ …

Sortase proteins play a crucial role as integral membrane proteins in anchoring bacterial
surface proteins by recognizing them through a Cell-Wall Sorting (CWS) motif and cleaving …

Gram-positive bacteria signify a surface organelle that decorates the cell surfaces using
Sortase enzymes. The mechanism of SrtC links to the formation of amide or peptide bonds …