The purine nucleoside adenosine acts via four distinct adenosine receptor subtypes: the
adenosine A1, A2A, A2B, and A3 receptor. They are all G protein-coupled receptors (GPCR) …

G-protein coupled receptors (GPCRs) modulate diverse cellular responses to the majority of
neurotransmitters and hormones within the human body. They exhibit much structural and …

Differentiation of functional dendritic cells (DCs) critically depends on the microenvironment.
DCs differentiate in hypoxic tumor sites and inflamed or damaged tissue. Because local …

Cancer is a complex expression of an altered state of cellular differentiation associated with
severe clinical repercussions. The effort to characterize this pathological entity to understand …

Adenosine is a ubiquitous signaling molecule whose physiological functions are mediated
by its interaction with four G-protein-coupled receptor subtypes, termed A1, A2A, A2B and …

Adenosine is an endogenous purine nucleoside that, following its release into the
extracellular space, binds to specific adenosine receptors expressed on the cell surface …

A 2B adenosine receptors are increasingly recognized as important orchestrators of
inflammation. A 2B receptor activation promotes the inflammatory response of mast cells …

Abnormal cancer metabolism occurs throughout the development of tumors. Recent studies
have shown that abnormal nucleotide metabolism not only accelerates the development of …

Adenosine can be released from a variety of cells throughout the body, as the result of
increased metabolic rates, in concentrations that can have a profound impact on the …

Obstructive nephropathy is characterized by an inflammatory state in the kidney, that is
promoted by cytokines and growth factors produced by damaged tubular cells, infiltrated …