Aging is the greatest risk factor for chronic human diseases, including many eye diseases.
Geroscience aims to understand the effects of the aging process on these diseases …

Mammalian photoreceptor outer segment renewal is a highly coordinated process that
hinges on timed cell signaling between photoreceptor neurons and the adjacent retinal …

Retinal pigment epithelial (RPE) cell dysfunction is a key driving force of AMD. RPE cells
form a metabolic interface between photoreceptors and choriocapillaris, performing …

Diseases leading to retinal cell loss can cause severe visual impairment and blindness. The
lack of effective therapies to address retinal cell loss and the absence of intrinsic …

Blindness poses a growing global challenge, with approximately 26% of cases attributed to
degenerative retinal diseases. While gene therapy, optogenetic tools, photosensitive …

Purpose To examine disease progression in age-related macular degeneration (AMD) at 2
distinct stages, progression to geographic atrophy (GA) versus GA expansion, by …

Proliferative vitreoretinal diseases (PVDs) encompass proliferative vitreoretinopathy (PVR),
epiretinal membranes, and proliferative diabetic retinopathy. These vision-threatening …

Since the discovery of induced pluripotent stem cell (iPSC) technology, there have been
many attempts to create cellular models of inherited retinal diseases (IRDs) for investigation …

In vitro differentiation of human pluripotent stem cells (hPSCs) into specialized tissues and
organs represents a powerful approach to gain insight into those cellular and molecular …

Importance Existing therapies to slow geographic atrophy (GA) enlargement in age-related
macular degeneration (AMD) have relatively modest anatomic efficacy, require intravitreal …