Cardiovascular and metabolic diseases (CVMD) are the leading causes of death worldwide,
underscoring the urgent necessity to develop new pharmacotherapies. Berberine (BBR) is …

Introduction: A number of plant-derived agents are used in many therapeutic areas.
Berberine, an important protoberberine alkaloid, is present in a number of medicinal plants …

Piperazine moiety is a cyclic molecule containing two nitrogen atoms in positions 1 and 4, as
well as four carbon atoms. Piperazine is one of the most sought heterocyclics for the …

The rapid growth of serious infections caused by antibiotic resistant bacteria, especially the
nosocomial ESKAPE pathogens, has been acknowledged by Governments and scientists …

A series of novel berberine-based imidazole derivatives as new type of antimicrobial agents
were developed and characterized. Most of them gave good antibacterial activity toward the …

A water-mediated C–H activation using sulfoxonium ylides is reported, providing a general,
green and step-economic approach to construct a C–C bond and varieties of useful N …

Ulcerative colitis (UC) is a chronic relapsing disease without satisfactory treatments, in which
intestinal inflammation and disrupted intestinal epithelial barrier are two main pathogeneses …

The endoplasmic reticulum (ER) is responsible for structural transformation or folding of de
novo proteins for transport to the Golgi. When the folding capacity of the ER is exceeded or …

Berberine, as a representative isoquinoline alkaloid, exhibits significant hypolipidemic
activity in both animal models and clinical trials. Recently, a large number of studies on the …

Abstract Indoleamine 2, 3-dioxygenase (IDO) and tryptophan 2, 3-dioxygenase (TDO) play a
pivotal role in regulating kynurenine catabolism pathway and immunosuppressive …