Higher eukaryotic cell nuclei are highly compartmentalized into bodies and structural
assemblies of specialized functions. Nuclear speckles/IGCs are one of the most prominent …

Alternative pre-mRNA splicing is a tightly controlled process conducted by the spliceosome,
with the assistance of several regulators, resulting in the expression of different transcript …

While nuclear compartmentalization is an essential feature of three-dimensional genome
organization, no genomic method exists for measuring chromosome distances to defined …

RNA helicases of the DEAH/RHA family form a large and conserved class of enzymes that
remodel RNA protein complexes (RNPs) by translocating along the RNA. Driven by ATP …

While dysregulation of RNA splicing has been recognized as an emerging target for cancer
therapy, the functional significance of RNA splicing and individual splicing factors in brain …

Stem cells regulate their self-renewal and differentiation fate outcomes through both
symmetric and asymmetric divisions. m 6 A RNA methylation controls symmetric commitment …

Nuclear speckles are small, membrane-less organelles that reside within the nucleus.
Nuclear speckles serve as a regulatory hub coordinating complex RNA metabolism steps …

The identification of the multiple endocrine neoplasia type 1 (MEN1) gene in 1997 has
shown that germline heterozygous mutations in the MEN1 gene located on chromosome …

The overall understanding of the molecular etiologies of intellectual disability (ID) and
developmental delay (DD) is increasing as next-generation sequencing technologies …

Abstract Zhu–Tokita–Takenouchi–Kim (ZTTK) syndrome, an intellectual disability syndrome
first described in 2016, is caused by heterozygous loss-of-function variants in SON. Its …