Atrial fibrillation (AF) is a highly prevalent arrhythmia, with substantial associated morbidity
and mortality. There have been significant management advances over the past 2 decades …

Abstract Calcium (Ca2+) ions are a key second messenger involved in the rhythmic
excitation and contraction of cardiomyocytes throughout the heart. Proper function of Ca2+ …

Rationale: Ca2+ homeostasis—a critical determinant of cardiac contractile function—is
critically regulated by SERCA2a (sarcoplasmic reticulum Ca2+-ATPase 2a). Our previous …

Cardiac ryanodine receptor (RyR2) gain-of-function mutations cause catecholaminergic
polymorphic ventricular tachycardia, a condition characterized by prominent ventricular …

Abstract cAMP is a ubiquitous second messenger responsible for the cellular effects of
multiple hormones and neurotransmitters via activation of its main effector, protein kinase A …

NO is known to modulate calcium handling and cellular signaling in the myocardium, but key
targets for NO in the heart remain unidentified. Recent reports have implied that NO can …

Oxidative stress may contribute to cardiac ryanodine receptor (RyR2) dysfunction in heart
failure (HF) and arrhythmias. Altered RyR2 domain–domain interaction (domain unzipping) …

Background Ryanodine receptors (RyR) mediate sarcoplasmic reticulum calcium (Ca2+)
release and influence myocyte Ca2+ homeostasis and arrhythmias. In cardiac myocytes …

In the heart, coupling between excitation of the surface membrane and activation of
contractile apparatus is mediated by Ca released from the sarcoplasmic reticulum (SR) …

Background Calmodulin (CaM) mutations have been identified recently in subjects with
congenital long QT syndrome (LQTS) or catecholaminergic polymorphic ventricular …