Peptide-based supramolecular hydrogels and their biotherapeutic applications

C Wu, W Liao, Y Zhang, Y Yan - Biomaterials Science, 2024 - pubs.rsc.org
In recent years, supramolecular hydrogels have made groundbreaking research progress in
biomedical fields such as drug delivery, biosensing, imaging analysis, and tissue …

Smart hydrogels delivered by high pressure aerosolization can prevent peritoneal adhesions

H Braet, PP Fransen, Y Chen, S Van Herck… - Journal of Controlled …, 2023 - Elsevier
Postoperative peritoneal adhesions occur in the majority of patients undergoing intra-
abdominal surgery and are one of the leading causes of hospital re-admission. There is an …

Histidine-containing amphiphilic peptide-based non-cytotoxic hydrogelator with antibacterial activity and sustainable drug release

B Hansda, J Majumder, B Mondal, A Chatterjee, S Das… - Langmuir, 2023 - ACS Publications
A histidine-based amphiphilic peptide (P) has been found to form an injectable transparent
hydrogel in phosphate buffer solution over a pH range from 7.0 to 8.5 with an inherent …

Analgesic Peptides: From Natural Diversity to Rational Design

K Gach-Janczak, M Biernat, M Kuczer… - Molecules, 2024 - mdpi.com
Pain affects one-third of the global population and is a significant public health issue. The
use of opioid drugs, which are the strongest painkillers, is associated with several side …

Synthesis of pH/temperature sensitive gelatin/peptide composite hydrogels and its characterization for potential controlled drug release applications

Z Zhang, S Zhou, X Wang, R Liang, X Sheng… - Materials Today …, 2023 - Elsevier
Conventional self-assembled peptide hydrogels have poor mechanical properties and tend
to release abruptly when they are used as drug carriers, limiting the application of these …

Fluorinated Peptide Hydrogels Result in Longer In Vivo Residence Time after Subcutaneous Administration

A Honfroy, J Bertouille, AM Turea… - …, 2024 - ACS Publications
Peptide-based hydrogels are of interest to biomedical applications. Herein, we have
explored the introduction of fluorinated amino acids in hydrogelator H-FQFQFK-NH2 (P1) to …

Common alterations in parallel metabolomic profiling of serum and spinal cord and mechanistic studies on neuropathic pain following PPARα administration

YY Zhao, ZJ Wu, S Hao, B Dong, Y Zheng, B Liu, J Li - Neuropharmacology, 2024 - Elsevier
Neuropathic pain (NP) is usually treated with analgesics and symptomatic therapy with poor
efficacy and numerous side effects, highlighting the urgent need for effective treatment …

Gut Microbiome and Serum Metabolites in Neuropathic Pain: The PPARα Perspective

YY Zhao, ZJ Wu, Y Du, Q Han, Y Bai, B Liu… - Behavioural Brain …, 2025 - Elsevier
Neuropathic pain (NP) is a chronic disease state centred on neuroinflammation with a high
prevalence and limited effective treatment options. Peroxisome proliferator-activated …

Sustained release of a human PD-L1 single-domain antibody using peptide-based hydrogels

J Heremans, RM Awad, J Bridoux, T Ertveldt… - European Journal of …, 2024 - Elsevier
Monoclonal antibodies (mAbs) targeting the immune checkpoint axis, which contains the
programmed cell death protein-1 (PD-1) and its ligand PD-L1, revolutionized the field of …

Peptide Sequence Variations Govern Hydrogel Stiffness: Insights from a Multi‐Scale Structural Analysis of H‐FQFQFK‐NH2 Peptide Derivatives

T De Maeseneer, T Cauwenbergh… - Macromolecular …, 2024 - Wiley Online Library
Throughout the past decades, amphipathic peptide‐based hydrogels have proven to be
promising materials for biomedical applications. Amphipathic peptides are known to adopt β …