Axons extend for tremendously long distances from the neuronal soma and make use of
localized mRNA translation to rapidly respond to different extracellular stimuli and …

MicroRNAs are post-transcriptional regulators of gene expression, crucial for neuronal
differentiation, survival, and activity. Age-related dysregulation of microRNA biogenesis …

Efficient neuronal function depends on the continued modulation of the local neuronal
proteome. Local protein synthesis plays a central role in tuning the neuronal proteome at …

Clinical manifestations typical of mitochondrial diseases are often present in various genetic
syndromes associated with intellectual disability, a condition leading to deficit in cognitive …

Mitochondria play several vital roles in the brain cells, especially in neurons to provide
synaptic energy (ATP), Ca2+ homeostasis, Reactive Oxygen Species (ROS) production …

Highlights•Many mRNAs are translated in developing and mature CNS axons in
vivo.•Axonal translation is critical for synaptogenesis, remodelling and survival.•RNA …

Mitochondria play a crucial role in energetic metabolism, signaling pathways, and overall
cell viability. Mitochondrial dysfunctions are known to cause a wide range of human …

Alzheimer's disease (AD), Parkinson's disease (PD), and Amyotrophic Lateral Sclerosis
(ALS) are representative neurodegenerative diseases (NDs) characterized by degeneration …

Mitochondria play a pivotal role in cellular energy-generating processes and are considered
master regulators of cell life and death fate. Mitochondrial function integrates signalling …

Age-related macular degeneration (AMD) is an ever-increasing, insidious disease which
reduces the quality of life of millions of elderly people around the world. AMD is …