In vivo two-photon calcium imaging (2PCI) is a technique used for recording neuronal
activity in the intact brain. It is based on the principle that, when neurons fire action …

The rapid and coordinated propagation of neural activity across the brain provides the
foundation for complex behavior and cognition. Technical advances across neuroscience …

GABAergic inhibition shapes the connectivity, activity and plasticity of the brain. A series of
exciting new discoveries provides compelling evidence that disruptions in a number of key …

Distinct genetic forms of autism are hypothesized to share a common increase in excitation-
inhibition (EI) ratio in cerebral cortex, causing hyperexcitability and excess spiking. We …

Hyper-reactivity to sensory input is a common and debilitating symptom in individuals with
autism spectrum disorders (ASD), but the neural basis underlying sensory abnormality is not …

Sensory abnormalities are commonly recognized as diagnostic criteria in autism spectrum
disorder (ASD), as reported in the last edition of the Diagnostic and Statistical Manual of …

Fragile X syndrome (FXS) is the most common inherited form of intellectual disability and the
leading monogenic cause of autism. The condition stems from loss of fragile X mental …

Fluorescence calcium imaging using a range of microscopy approaches, such as two-
photon excitation or head-mounted “miniscopes,” is one of the preferred methods to record …

Recent advances in genomics have revealed a wide spectrum of genetic variants
associated with neurodevelopmental disorders at an unprecedented scale. An increasing …

The mechanistic underpinnings of autism remain a subject of debate and controversy. Why
do individuals with autism share an overlapping set of atypical behaviors and symptoms …