Simple Summary Glioblastomas are the most common and aggressive brain tumors in
adults, with a median survival of 15 months. Treatment is surgical removal, followed by …

Cell-penetrating peptides (CPP) are promising tools for the transport of a broad range of
compounds into cells. Since the discovery of the first members of this peptide family, many …

Central nervous system (CNS) diseases are among the most difficult to treat, mainly
because the vast majority of the drugs fail to cross the blood-brain barrier (BBB) or to reach …

The cytosolic delivery of various substrates in 3D multicellular spheroids by thiol-mediated
uptake is reported. This is important because most orthodox systems, including polycationic …

One of the main hallmarks of tuberculosis (TB) is the ability of the causative agent to
transform into a stage of dormancy and the capability of long persistence in the host …

Mycobacterium tuberculosis is an intracellular pathogen and the uptake of the
antimycobacterial compounds by host cells is limited. Novel antimycobacterials effective …

Malignant melanoma is one of the most aggressive and resistant tumor types, with high
metastatic properties. Because of the lack of suitable chemotherapeutic agents for treatment …

Tumor spheroids are one of the well-characterized 3D culture systems bearing close
resemblance to the physiological tissue organization and complexity of avascular solid …

Adult-onset brain cancers, such as glioblastomas, are particularly lethal. People with
glioblastoma multiforme (GBM) do not anticipate living for more than 15 months if there is no …

Pancreatic adenocarcinoma is one of the tumours with the worst prognosis, with a 5-year
survival rate of 5–10%. Our aim was to find and optimise peptide-based drug conjugates …