Molecular and cellular insights into the development of uterine fibroids

A Machado-Lopez, C Simón, A Mas - International journal of molecular …, 2021 - mdpi.com
Uterine leiomyomas represent the most common benign gynecologic tumor. These hormone-
dependent smooth-muscle formations occur with an estimated prevalence of~ 70% among …

Racial disparity in uterine leiomyoma: new insights of genetic and environmental burden in myometrial cells

NH Khan, R McNally, JJ Kim… - Molecular human …, 2024 - academic.oup.com
Uterine leiomyoma (LM), also known as uterine fibroids, are common gynecological tumors
and can reach a prevalence of 70% among women by the age of 50 years. Notably, the LM …

Candidate genes for age at menarche are associated with uterine leiomyoma

I Ponomarenko, E Reshetnikov, A Polonikov… - Frontiers in …, 2021 - frontiersin.org
Age at menarche (AAM) is an important marker of the pubertal development and function of
the hypothalamic–pituitary–ovarian system. It was reported as a possible factor for a risk of …

Genetic predisposition to uterine leiomyoma is determined by loci for genitourinary development and genome stability

N Välimäki, H Kuisma, A Pasanen, O Heikinheimo… - Elife, 2018 - elifesciences.org
Uterine leiomyomas (ULs) are benign tumors that are a major burden to women's health. A
genome-wide association study on 15,453 UL cases and 392,628 controls was performed …

A multi-stage genome-wide association study of uterine fibroids in African Americans

JN Hellwege, JM Jeff, LA Wise, CS Gallagher… - Human genetics, 2017 - Springer
Uterine fibroids are benign tumors of the uterus affecting up to 77% of women by
menopause. They are the leading indication for hysterectomy, and account for $34 billion …

Role of DNA damage and repair mechanisms in uterine fibroid/leiomyomas: a review

SM Toprani, V Kelkar Mane - Biology of Reproduction, 2021 - academic.oup.com
There has been a significant annual increase in the number of cases of uterine leiomyomas
or fibroids (UF) among women of all races and ages across the world. A fortune is usually …

Genetic basis of eugonadal and hypogonadal female reproductive disorders

T Trofimova, D Lizneva, L Suturina, W Walker… - Best practice & research …, 2017 - Elsevier
Highlights•Disorders of the human reproductive system can be classified based on the
functional activity of the gonads as either hypogonadal (low estrogen state) or eugonadal …

Replication of GWAS loci revealed the moderate effect of TNRC6B locus on susceptibility of Saudi women to develop uterine leiomyomas

NS Bondagji, FA Morad, AAA Al‐Nefaei… - Journal of Obstetrics …, 2017 - Wiley Online Library
Aim Uterine leiomyomas (UL) are smooth muscular nodes, whose growth is dependant up
on the complex interplay of hormones with genes and uterine physiology. Global statistics …

Risk of uterine leiomyoma based on BET1L rs2280543 single nucleotide polymorphism and vegetarian diet

SC Lee, YH Chou, DM Tantoh, SY Hsu, ON Nfor… - BMC Women's …, 2022 - Springer
Abstract Background Bet1 Golgi vesicular membrane trafficking protein-like (BET1L)
rs2280543 single nucleotide polymorphism (SNP) and diet have been independently …

[HTML][HTML] Genetic determinants of uterine fibroid size in the multiethnic NIEHS uterine fibroid study

B Aissani, K Zhang, H Wiener - International journal of molecular …, 2015 - ncbi.nlm.nih.gov
We conducted a follow-up association study across extended candidate chromosomal
regions for uterine leiomyoma (UL), or fibroids, to search for loci influencing the size of UL in …