Blood groups in infection and host susceptibility

L Cooling - Clinical microbiology reviews, 2015 - Am Soc Microbiol
Blood group antigens represent polymorphic traits inherited among individuals and
populations. At present, there are 34 recognized human blood groups and hundreds of …

Animal Enterotoxigenic Escherichia coli

JD Dubreuil, RE Isaacson, DM Schifferli - EcoSal Plus, 2016 - Am Soc Microbiol
Enterotoxigenic Escherichia coli (ETEC) is the most common cause of E. coli diarrhea in
farm animals. ETEC are characterized by the ability to produce two types of virulence factors …

Protein-carbohydrate interactions studied by NMR: from molecular recognition to drug design

M del Carmen Fernandez-Alonso, D Diaz… - Current Protein and …, 2012 - benthamdirect.com
Diseases that result from infection are, in general, a consequence of specific interactions
between a pathogenic organism and the cells. The study of host-pathogen interactions has …

Histo-blood group antigens as mediators of infections

JE Heggelund, A Varrot, A Imberty, U Krengel - Current opinion in structural …, 2017 - Elsevier
Highlights•Cells are covered by a dense, protective glycan layer, the glycocalyx.•Viruses,
bacteria and fungi exploit these glycans to gain entry to the host.•The mucus layer covering …

Cholera toxin as a probe for membrane biology

AK Kenworthy, SS Schmieder, K Raghunathan… - Toxins, 2021 - mdpi.com
Cholera toxin B-subunit (CTxB) has emerged as one of the most widely utilized tools in
membrane biology and biophysics. CTxB is a homopentameric stable protein that binds …

Biologic roles of the ABH and Lewis histo‐blood group antigens part I: infection and immunity

CP Stowell, SR Stowell - Vox sanguinis, 2019 - Wiley Online Library
The ABH and Lewis antigens were among the first of the human red blood cell
polymorphisms to be identified and, in the case of the former, play a dominant role in …

Bacterial toxin inhibitors based on multivalent scaffolds

TR Branson, WB Turnbull - Chemical Society Reviews, 2013 - pubs.rsc.org
Protein toxins released by certain intestinal bacteria are the cause of many diarrhoeal
diseases including cholera and travellers' diarrhoea. The toxins enter their target cells by …

Synthesis and screening of a library of Lewisx deoxyfluoro-analogues reveals differential recognition by glycan-binding partners

K Hollingsworth, A Di Maio, SJ Richards… - Nature …, 2024 - nature.com
Glycan-mediated interactions play a crucial role in biology and medicine, influencing
signalling, immune responses, and disease pathogenesis. However, the use of glycans in …

Crystal structures of cholera toxin in complex with fucosylated receptors point to importance of secondary binding site

JB Heim, V Hodnik, JE Heggelund, G Anderluh… - Scientific reports, 2019 - nature.com
Cholera is a life-threatening diarrhoeal disease caused by the human pathogen Vibrio
cholerae. Infection occurs after ingestion of the bacteria, which colonize the human small …

Toward glycomaterials with selectivity as well as affinity

SJ Richards, MI Gibson - JACS Au, 2021 - ACS Publications
Multivalent glycosylated materials (polymers, surfaces, and particles) often show high affinity
toward carbohydrate binding proteins (eg, lectins) due to the nonlinear enhancement from …