Polycyclic aromatic hydrocarbons: from metabolism to lung cancer

B Moorthy, C Chu, DJ Carlin - Toxicological Sciences, 2015 - academic.oup.com
Excessive exposure to polycyclic aromatic hydrocarbons (PAHs) often results in lung cancer,
a disease with the highest cancer mortality in the United States. After entry into the lung …

Biological impact of environmental polycyclic aromatic hydrocarbons (ePAHs) as endocrine disruptors

Y Zhang, S Dong, H Wang, S Tao, R Kiyama - Environmental pollution, 2016 - Elsevier
Polycyclic aromatic hydrocarbons (PAHs) are often detected in the environment and are
regarded as endocrine disruptors. We here designated mixtures of PAHs in the environment …

Sex differences in lung cancer susceptibility: a review

C Kiyohara, Y Ohno - Gender medicine, 2010 - Elsevier
Background: Several epidemiologic and molecular epidemiologic studies have indicated
that, for a given number of cigarettes smoked, women may be at higher risk of lung cancer …

DNA and protein adducts in human tissues resulting from exposure to tobacco smoke

DH Phillips, S Venitt - International journal of cancer, 2012 - Wiley Online Library
Tobacco smoke contains a variety of genotoxic carcinogens that form adducts with DNA and
protein in the tissues of smokers. Not only are these biochemical events relevant to the …

Sex differences in risk of lung cancer: expression of genes in the PAH bioactivation pathway in relation to smoking and bulky DNA adducts

S Mollerup, G Berge, R Bæra, V Skaug… - … journal of cancer, 2006 - Wiley Online Library
It is controversial whether women have a higher lung cancer susceptibility compared to men.
We previously reported higher levels of smoking‐related bulky DNA adducts in female …

Pharmacogenetics and Regulation of Human Cytochrome P450 1B1: Implications in Hormone-Mediated Tumor Metabolism and a Novel Target for Therapeutic …

TM Sissung, DK Price, A Sparreboom, WD Figg - Molecular cancer research, 2006 - AACR
Several of the hormone-mediated cancers (breast, endometrial, ovarian, and prostate)
represent major cancers in both incidence and mortality rates. The etiology of these cancers …

Differential effects of nitro-PAHs and amino-PAHs on cytokine and chemokine responses in human bronchial epithelial BEAS-2B cells

J Øvrevik, VM Arlt, E Øya, E Nagy, S Mollerup… - Toxicology and applied …, 2010 - Elsevier
Nitro-polycyclic aromatic hydrocarbons (nitro-PAHs) are found in diesel exhaust and air
pollution particles. Along with other PAHs, many nitro-PAHs possess mutagenic and …

A specific interleukin-1B haplotype correlates with high levels of IL1B mRNA in the lung and increased risk of non-small cell lung cancer

NE Landvik, K Hart, V Skaug, LB Stangeland… - …, 2009 - academic.oup.com
Epidemiological evidence suggests a relationship between chronic inflammation and lung
cancer. Inflammation in the lung may be modulated by host genetic factors such as …

Association of polycyclic aromatic hydrocarbons (PAHs) and lead co-exposure with child physical growth and development in an e-waste recycling town

X Xu, J Liu, C Huang, F Lu, YM Chiung, X Huo - Chemosphere, 2015 - Elsevier
Informal e-waste recycling activities results in serious environmental pollution of PAHs. We
evaluated the body burden of 16 PAH congeners and potential health risks for children. A …

Importance of CYP1A1 and CYP1B1 in bioactivation of benzo [a] pyrene in human lung cell lines

H Uppstad, S Øvrebø, A Haugen, S Mollerup - Toxicology letters, 2010 - Elsevier
Polycyclic aromatic hydrocarbons are ubiquitous environmental pollutants classified as
carcinogens in humans and rodents. The cytochromes P4501A1 and 1B1 have both shown …