The making and breaking of clots orchestrated by the thrombotic and thrombolytic serine
protease cascades are critical determinants of morbidity and mortality during infection and …

Acute Kidney Injury (AKI) is currently recognized as a life-threatening disease, leading to an
exponential increase in morbidity and mortality worldwide. At present, AKI is characterized …

Acute kidney injury (AKI) is a common and serious clinical syndrome that involves complex
interplay between different cellular, molecular, metabolic and immunologic mechanisms …

Ischaemia–reperfusion injury (IRI) is an inevitable process in transplantation and results in
inflammation and immune system activation. Alpha-1 antitrypsin (AAT) has anti-inflammatory …

Free heme toxicity in the vascular endothelium is critical for the pathogenesis of hemolytic
disorders including sickle cell disease. In the current study, it is demonstrated that human …

Alpha 1-antitrypsin is one of the first protein therapeutics introduced on the market more than
30 years ago, and to date, it is indicated only for the treatment of the severe forms of a …

Protecting tissues from excessive inflammation by glucocorticoids results in an effective
blockade of inflammation; however, it does not instigate processes of inflammatory …

Acute kidney injury (AKI) is a very common complication with high morbidity and mortality
rates and no fundamental treatment. In this study, we investigated whether the hepatocyte …

Introduction Renal ischemia reperfusion injury is a major cause of perioperative acute
kidney injury. Alpha-1-antitrypsin (AAT), a protease inhibitor, might improve outcomes by …

Human alpha-1-antitrypsin (AAT) encoded by the SERPINA1 gene, is an acute phase
glycoprotein that regulates inflammatory responses via both protease inhibitory and non …