New insight in cardiorenal syndrome: from biomarkers to therapy

G Gallo, O Lanza, C Savoia - International Journal of Molecular Sciences, 2023 - mdpi.com
Cardiorenal syndrome consists in the coexistence of acute or chronic dysfunction of heart
and kidneys resulting in a cascade of feedback mechanisms and causing damage to both …

Cardiorenal syndrome: new pathways and novel biomarkers

G Gembillo, L Visconti, MA Giusti, R Siligato, A Gallo… - Biomolecules, 2021 - mdpi.com
Cardiorenal syndrome (CRS) is a multi-organ disease characterized by the complex
interaction between heart and kidney during acute or chronic injury. The pathogenesis of …

From proteins to ligands: decoding deep learning methods for binding affinity prediction

R Gorantla, A Kubincova, AY Weiße… - Journal of Chemical …, 2023 - ACS Publications
Accurate in silico prediction of protein–ligand binding affinity is important in the early stages
of drug discovery. Deep learning-based methods exist but have yet to overtake more …

Beyond the cardiorenal syndrome: pathophysiological approaches and biomarkers for renal and cardiac crosstalk

ON Buliga-Finis, A Ouatu, MC Badescu, N Dima… - Diagnostics, 2022 - mdpi.com
Cardiorenal syndrome encompasses complex multifactorial facets and carries significant
morbidity and mortality worldwide. The bi-directional relationship between the heart and …

Molecular crosstalk between COVID-19 and Alzheimer's disease using microarray and RNA-seq datasets: A system biology approach

T Premkumar, S Sajitha Lulu - Frontiers in Medicine, 2023 - frontiersin.org
Objective Coronavirus disease 2019 (COVID-19) is an infectious disease caused by Severe
Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2). The clinical and …

New insight into mechanisms of cardiovascular diseases: an integrative analysis approach to identify theranoMiRNAs

F Sessa, M Salerno, M Esposito, G Cocimano… - International Journal of …, 2023 - mdpi.com
MiRNAs regulate both physiological and pathological heart functions. Altered expression of
miRNAs is associated with cardiovascular diseases (CVDs), making miRNAs attractive …

Identification of miRNAs and related hub genes associated with the triple negative breast cancer using integrated bioinformatics analysis and in vitro approach

M Shuaib, KS Prajapati, AK Singh… - Journal of …, 2022 - Taylor & Francis
Triple negative breast cancer (TNBC) is an aggressive breast cancer subtype generally
associated with younger women. Due to the lack of suitable drugable targets in TNBC, the …

Cardiorenal syndrome type 3 review

R Okpara, C Pena, K Nugent - Cardiology in Review, 2024 - journals.lww.com
The management of patients with complex comorbidity involving several organ systems can
use an approach focused on each organ system independently or can use an approach …

Identification of the key miRNAs and genes associated with the regulation of non-small cell lung cancer: a network-based approach

Z Shafat, MM Ahmed, FN Almajhdi, T Hussain… - Genes, 2022 - mdpi.com
Lung cancer is the major cause of cancer-associated deaths across the world in both men
and women. Lung cancer consists of two major clinicopathological categories, ie, small cell …

Identification and validation of pathogenic genes in sepsis and associated diseases by integrated bioinformatics approach

MM Ahmed, A Zaki, A Alhazmi, KF Alsharif, HA Bagabir… - Genes, 2022 - mdpi.com
Sepsis is a clinical syndrome with high mortality and morbidity rates. In sepsis, the abrupt
release of cytokines by the innate immune system may cause multiorgan failure, leading to …