The MDM2 and MDMX (also known as HDMX and MDM4) proteins are deregulated in many
human cancers and exert their oncogenic activity predominantly by inhibiting the p53 tumour …

The p53 tumor suppressor is a key transcription factor regulating cellular pathways such as
DNA repair, cell cycle, apoptosis, angiogenesis, and senescence. It acts as an important …

Triple-negative breast cancers (TNBC) frequently inactivate p53, increasing their
aggressiveness and therapy resistance. We identified an unexpected protein vulnerability in …

Cancer cells are characterized by a higher rate of protein turnover and greater demand for
protein homeostasis compared to normal cells. In this scenario, the ubiquitin–proteasome …

The really interesting genes (RING)-finger-containing oncoprotein, Mdm2, is a promising
drug target for cancer therapy. A key Mdm2 function is to promote ubiquitylation and …

Dysregulated microRNAs (miRNAs) have an important role in many malignant tumors.
However, elucidating the roles of miRNAs in cancer biology, especially in epithelial cancers …

It is now clear that functional p53 is critical to protect the genome from alterations that lead to
tumorigenesis. However, with the myriad of cellular stresses and pathways linked to p53 …

In eukaryotic cells, degradation of most intracellular proteins is realized by proteasomes.
The substrates for proteolysis are selected by the fact that the gate to the proteolytic chamber …

Since the discovery of the first MDM2 inhibitors, we have gained deeper insights into the
cellular roles of MDM2 and p53. In this review, we focus on MDM2 inhibitors that bind to the …

Summary p53 induces cell death upon DNA damage, but this may not confer all of its tumor
suppressor activity. We report that p53 activation enhances the processivity of DNA …