Amino acids are the building blocks of protein synthesis. They are structural elements and
energy sources of cells necessary for normal cell growth, differentiation and function. Amino …

Protein posttranslational modifications (PTMs) refer to the breaking or generation of covalent
bonds on the backbones or amino acid side chains of proteins and expand the diversity of …

Epigenetics governs a chromatin state regulatory system through five key mechanisms: DNA
modification, histone modification, RNA modification, chromatin remodeling, and non-coding …

Drug resistance remains a major challenge in cancer treatment, necessitating the
development of novel strategies to overcome it. Protein arginine methyltransferases …

Abstract N6-methyladenosine (m6A), the most abundant mRNA modification in mammalian
cells, is responsible for mRNA stability and alternative splicing. The METTL3-METTL14 …

Protein arginine N-methyltransferases (PRMT) are a family of S-adenosyl-l-methionine
(SAM)-dependent enzymes that transfer methyl-groups to the ω-N of arginyl residues in …

Exploration in the field of epigenetics has revealed that protein arginine methyltransferases
(PRMTs) contribute to disease, and this has given way to the development of specific small …

Pancreatic adenocarcinoma is a lethal cancer with poor response to chemotherapy and
immune checkpoint inhibitors. Recent studies suggest that epigenetic alterations contribute …

Abstract Purpose Protein arginine methyltransferases (PRMTs) regulate several signal
transduction pathways involved in cancer progression. Recently, it has been reported that …

Megakaryocytes (Mks) in bone marrow are heterogeneous in terms of polyploidy. They not
only produce platelets but also support the self-renewal of hematopoietic stem cells and …