The discovery in 2001 of a G protein-coupled receptor family, subsequently termed trace
amine-associated receptors (TAAR), triggered a resurgence of interest in so-called trace …

There is a need for innovation with respect to therapeutics in psychiatry. Available evidence
indicates that the trace amine-associated receptor 1 (TAAR1) agonist SEP-363856 is …

Ulotaront (SEP-363856) is a trace-amine associated receptor 1 (TAAR1) agonist with 5-
HT1A receptor agonist activity in Phase 3 clinical development, with FDA Breakthrough …

Pharmacophore modeling, molecular docking, and in silico ADME studies have been
carried out to determine the binding mode and drug likeliness profile of acyl 1, 3, 4 …

Early diagnosis of Parkinson's disease (PD) remains a challenge to date. New evidence
highlights the potential clinical value of circulating trace amines (TAs) in early-stage PD and …

Human trace amine-associated receptor subtype 1 (hTAAR1) is a G protein-coupled
receptor that has therapeutic potential for multiple diseases, including schizophrenia, drug …

A focused in-house library of about 1000 compounds comprising various heterocyclic motifs
in combination with structural fragments similar to β-phenylethylamine or tyramine was …

Dipeptidyl peptidase-4 (DPP-4) is the vital enzyme that is responsible for inactivating
intestinal peptides glucagon like peptide-1 (GLP-1) and Gastric inhibitory polypeptide (GIP) …

Trace amines (TAs) are endogenous neuromodulators that play a functional role in the
synaptic transmission within central nervous system (CNS), targeting trace amine …

Human monoamine transporters (MATs) are cation transporters critically involved in
neuronal signal transmission. While inhibitors of MATs have been intensively studied, their …