Mesenchymal stem cell (MSC) therapies have demonstrated efficacy in cartilage repair in
animal and clinical studies. The efficacy of MSC-based therapies which was previously …

The role of native (not culture-expanded) joint-resident mesenchymal stem cells (MSCs) in
the repair of joint damage in osteoarthritis (OA) is poorly understood. MSCs differ from bone …

Background: Bone marrow aspirate concentrate (BMAC) has emerged as a novel treatment
for pathology of the knee. Despite containing a limited number of stem cells, BMAC serves …

Background: Articular cartilage injury is frequently encountered, yet treatment options
capable of providing durable cartilage repair are limited. Purpose: To investigate the …

Purpose Bone marrow concentrate (BMC) and platelet-rich plasma (PRP) are used
extensively in regenerative medicine. The aim of this study was to determine differences in …

Purpose The aim of this systematic review is to examine the available clinical evidence in
the literature to support mesenchymal stem cell (MSC) treatment strategies in orthopaedics …

Articular cartilage has a limited capacity to repair following injury. Early intervention is
required to prevent progression of focal traumatic chondral and osteochondral defects to …

Objective To create a treatment algorithm for focal grade 3 or 4 cartilage defects of the knee
using both classic and novel cartilage restoration techniques. Design A comprehensive …

Background: Chondral lesions in athletically active patients cause considerable morbidity,
and treatment with existing cell-based therapies can be challenging. Bone marrow has been …

Bone marrow obtained by iliac crest aspiration is a common source for harvesting
mesenchymal stem cells, other progenitor cells, and associated cytokine/growth factors …