Diagnosis of thyroid nodules

EK Alexander, ES Cibas - The lancet Diabetes & endocrinology, 2022 - thelancet.com
Thyroid nodules are common, usually asymptomatic, and often pose minimal risk to the
affected patient. However, 10–15% prove malignant and serve as the rationale for …

Thyroseq v3, Afirma GSC, and microRNA panels versus previous molecular tests in the preoperative diagnosis of indeterminate thyroid nodules: a systematic review …

CA Silaghi, V Lozovanu, CE Georgescu… - Frontiers in …, 2021 - frontiersin.org
Background Molecular tests are being used increasingly as an auxiliary diagnostic tool so
as to avoid a diagnostic surgery approach for cytologically indeterminate thyroid nodules …

Molecular diagnostics in the evaluation of thyroid nodules: current use and prospective opportunities

J Patel, J Klopper, EE Cottrill - Frontiers in endocrinology, 2023 - frontiersin.org
Thyroid cancer is the most common endocrine malignancy with an estimated 43,800 new
cases to be diagnosed in 2022 and representing the 7th most common cancer in women …

Real-world performance of the Afirma Genomic Sequencing Classifier (GSC)—a meta-analysis

CE Nasr, M Andrioli, M Endo, RM Harrell… - The Journal of …, 2023 - academic.oup.com
Abstract Context The Afirma® GSC aids in risk stratifying indeterminate thyroid nodule
cytology (ITN). The 2018 GSC validation study (VS) reported a sensitivity (SN) of 91 …

Clinical use of molecular data in thyroid nodules and cancer

AS Alzahrani - The Journal of Clinical Endocrinology & …, 2023 - academic.oup.com
Over the past 3 decades, advances in the molecular genetics of thyroid cancer (TC) have
been translated into diagnostic tests, prognostic markers, and therapeutic agents. The main …

Thyroid nodules: diagnosis and management

G Grani, M Sponziello, S Filetti, C Durante - Nature Reviews …, 2024 - nature.com
Thyroid nodules, with a prevalence of almost 25% in the general population, are a common
occurrence. Their prevalence varies considerably depending on demographics such as age …

The effect modification of ultrasound risk classification on molecular testing in predicting the risk of malignancy in cytologically indeterminate thyroid nodules

TX Hu, DT Nguyen, M Patel, K Beckett, M Douek… - Thyroid, 2022 - liebertpub.com
Background: Thyroid nodules with indeterminate cytology are increasingly subjected to
molecular testing. We evaluated the diagnostic performances of Afirma Genomic …

Diagnostic performance of the second-generation molecular tests in the assessment of indeterminate thyroid nodules: A systematic review and meta-analysis

E Lee, S Terhaar, L McDaniel, D Gorelik… - American journal of …, 2022 - Elsevier
Objective The objective of this systematic review and meta-analysis was to evaluate the
diagnostic performance of the second-generation molecular tests in the diagnosis of thyroid …

[HTML][HTML] Preoperative evaluation of thyroid nodules–Diagnosis and management strategies

TD Antonia, LI Maria, GG Ancuta-Augustina - Pathology-Research and …, 2023 - Elsevier
Thyroid cancer is the most common endocrine malignancy, with increasing incidence over
the past few decades. Fine needle aspiration (FNA) biopsy is the gold standard for …

Repeat fine needle aspiration cytology refines the selection of thyroid nodules for Afirma gene expression classifier testing

M Nishino, R Mateo, H Kilim, A Feldman, A Elliott… - Thyroid, 2021 - liebertpub.com
Background: Molecular testing (MT) refines risk stratification for thyroid nodules that are
indeterminate for cancer by fine needle aspiration (FNA) cytology. Criteria for selecting …