[HTML][HTML] Mechanotransduction through protein stretching
Cells sense and respond to subtle changes in their physicality, and via a myriad of different
mechanosensitive processes, convert these physical cues into chemical and biochemical …
mechanosensitive processes, convert these physical cues into chemical and biochemical …
SpyMask enables combinatorial assembly of bispecific binders
CL Driscoll, AH Keeble, MR Howarth - Nature Communications, 2024 - nature.com
Bispecific antibodies are a successful and expanding therapeutic class. Standard
approaches to generate bispecifics are complicated by the need for disulfide …
approaches to generate bispecifics are complicated by the need for disulfide …
Genetically Encoded Photocaged Proteinogenic and Non‐Proteinogenic Amino Acids
Photocaged amino acids could be genetically encoded into proteins via genetic code
expansion (GCE) and constitute unique tools for innovative protein engineering. There are a …
expansion (GCE) and constitute unique tools for innovative protein engineering. There are a …
Engineered reversible inhibition of SpyCatcher reactivity enables rapid generation of bispecific antibodies
C Hentrich, M Putyrski, H Hanuschka, W Preis… - Nature …, 2024 - nature.com
The precise regulation of protein function is essential in biological systems and a key goal in
chemical biology and protein engineering. Here, we describe a straightforward method to …
chemical biology and protein engineering. Here, we describe a straightforward method to …
SpyTag Peptide with Alkoxyl Aspartic Acids for pH-Dependent Activation of the SpyCatcher/Tag System
S Che, H Konno, K Makabe - Bioconjugate Chemistry, 2024 - ACS Publications
The SpyCatcher/SpyTag system is a protein pair that forms a covalent isopeptide bond
without an additional energy supply. The ability to connect fused proteins makes this system …
without an additional energy supply. The ability to connect fused proteins makes this system …