ISPAD Clinical Practice Consensus Guidelines 2018: Diabetic ketoacidosis and the
hyperglycemic hyperosmolar state Page 1 ISPAD CLINICAL PRACTICE CONSENSUS …

Highlights•Genetic dissection of ENaC mediated sodium transport validate novel drug
targets.•Signaling pathways controlling ENaC activity identifies novel drug targets.• …

The article presents a chapter of the guidelines on pediatric diabetes in the International
Society for Pediatric and Adolescent Diabetes (ISPAD) Clinical Practice Consensus …

A new understanding of renal potassium balance has emerged as the molecular
underpinnings of potassium secretion have become illuminated, highlighting the key roles of …

It is now recognized that the metabolic disorders observed in diabetes are not, or not only
due to the lack of insulin or insulin resistance, but also to elevated glucagon secretion …

Potassium Kir4. 1/5.1 channels are abundantly expressed at the basolateral membrane of
principal cells in the cortical collecting duct (CCD), where they are thought to modulate …

Abstract The Epithelial Na+ Channel, ENaC, comprised of 3 subunits (αβγ, or sometimes
δβγENaC), plays a critical role in regulating salt and fluid homeostasis in the body. It …

The epithelial sodium channel (ENaC) is one of the central effectors involved in regulation of
salt and water homeostasis in the kidney. To study mechanisms of ENaC regulation, we …

Renal Na+ reabsorption, facilitated by the epithelial Na+ channel (ENaC), is subject to
multiple forms of control to ensure optimal body blood volume and pressure through altering …

Epithelial K+ channels are essential for maintaining electrolyte and fluid homeostasis in the
kidney. It is recognized that basolateral inward‐rectifying K+ (Kir) channels play an important …