Natural compounds from various plants, microorganisms and marine species play an
important role in the discovery novel components that can be successfully used in numerous …

N-heterocyclic carbenes (NHCs) are organic compounds that typically mimic the chemical
properties of phosphines. NHCs have made a significant impact on the field of coordination …

Thiazole and oxazole are compounds with a heterocyclic nucleus that have attracted the
attention of medicinal chemistry due to the great variety of biological activities that they …

Despite the fact that bacterial infections are one of the leading causes of death worldwide
and that mortality rates are increasing at alarming rates, no new antibiotics have been …

In this study, we report the synthesis and structural characterization of a series of
thiosemicarbazone and 4-thiazolidinones derivatives, as well as their in vitro antiproliferative …

Accumulating evidence shows that hallmarks of cancer include:“genetic and epigenetic
alterations leading to inactivation of cancer suppressors, overexpression of oncogenes …

Triterpene saponins (saponosides) are found in a variety of higher plants and display a wide
range of pharmacological activities, including expectorant, anti-inflamatory, vasoprotective …

Background: Among the important key modulators of the tumor microenvironment and
hypoxia is a family of enzymes named carbonic anhydrases. Herein, 11 novel sulfonamide …

Abstract Floxuridine (5'-fluorodeoxyuridine, FUdR) acts as an inhibitor of DNA replication by
binding to thymidylate synthase and is widely used to treat colorectal cancer. FUdR is also …

Anticancer drugs research and development have been the largest market area in the
pharmaceutical industry in terms of the number of project, clinical trials and spending. In the …