Translation of scaffold-based bone tissue engineering (BTE) therapies to clinical use
remains, bluntly, a failure. This dearth of translated tissue engineering therapies (including …

Biomaterial scaffolds have been extensively used to deliver growth factors to induce new
bone formation. The pharmacokinetics of growth factor delivery has been a critical regulator …

Peptides, short protein fragments, can emulate the functions of their full-length native
counterparts. Peptides are considered potent recombinant protein alternatives due to their …

Limitations of current treatment options for critical size bone defects create a significant
clinical need for tissue engineered bone strategies. This review describes how control over …

Growth factor activity is localized within the natural extracellular matrix (ECM) by specific
noncovalent interactions with core ECM biomolecules, such as proteins and proteoglycans …

BMPs are members of the transforming growth factor-β (TGF-β) superfamily and have been
extensively studied due to their excellent osteoinductive ability and multiple functions …

Many strategies for controlling the fate of transplanted stem cells rely on the concurrent
delivery of soluble growth factors that have the potential to produce undesirable secondary …

Stem cells are a powerful resource for many applications including regenerative medicine,
patient-specific disease modeling, and toxicology screening. However, eliciting the desired …

Despite the high innate regenerative capacity of bone, large osseous defects fail to heal and
remain a clinical challenge. Healing such defects requires the formation of large amounts of …

In the present study, we fabricated an efficient, simple biomimetic scaffold to stimulate
osteogenic differentiation of mesenchymal stem cells (MSCs). Electrospun poly L-lactic acid …