The ability of epithelial cells to organize through cell–cell adhesion into a functioning
epithelium serves the purpose of a tight epithelial protective barrier. Contacts between …

Angiogenesis is the formation of new capillaries from pre-existing vasculature, which plays a
critical role in the pathogenesis of several inflammatory autoimmune diseases such as …

Endothelial cells line the lumen of all blood vessels and play a critical role in maintaining the
barrier function of the vasculature. Sealing of the vessel wall between adjacent endothelial …

Breaching endothelial cells (ECs) is a decisive step in the migration of leukocytes from the
vascular lumen to the extravascular tissue, but fundamental aspects of this response remain …

The signalling activity of cell adhesion molecules (CAMs) such as cadherins,
immunoglobulin-like CAMs or integrins has long been considered to be a direct …

Junctional adhesion molecules (JAM)-A,-B and-C are cell-cell adhesion molecules of the
immunoglobulin superfamily which are expressed by a variety of tissues, both during …

Proteolytic cleavage represents a unique and irreversible posttranslational event regulating
the function and half-life of many intracellular and extracellular proteins. The …

Junctional adhesion molecules (JAMs) are a family of adhesion molecules localized at the
tight junction of polarized cells and on the cell surface of leukocytes. The last 20 years of …

Objective Patients with systemic lupus erythematosus (SLE) have a notable increase in
atherothrombotic cardiovascular disease (CVD) which is not explained by the Framingham …

Mucosal surface layers are the critical borders throughout epithelial membranes. These
epithelial cells segregate luminal material from external environments. However, mucosal …