Anabolic–androgenic steroids: How do they work and what are the risks?

P Bond, DL Smit, W de Ronde - Frontiers in Endocrinology, 2022 - frontiersin.org
Anabolic–androgenic steroids (AAS) are a class of hormones that are widely abused for
their muscle-building and strength-increasing properties in high, nontherapeutic, dosages …

Sex differences in the hypothalamic–pituitary–adrenal axis' response to stress: an important role for gonadal hormones

AL Heck, RJ Handa - Neuropsychopharmacology, 2019 - nature.com
The hypothalamic–pituitary–adrenal (HPA) axis, a neuroendocrine network that controls
hormonal responses to internal and external challenges in an organism's environment …

Sex differences in endothelial function important to vascular health and overall cardiovascular disease risk across the lifespan

AE Stanhewicz, MM Wenner… - American Journal of …, 2018 - journals.physiology.org
Diseases of the cardiovascular system are the leading cause of morbidity and mortality in
men and women in developed countries, and cardiovascular disease (CVD) is becoming …

Gonadal steroid hormones and the hypothalamo–pituitary–adrenal axis

RJ Handa, MJ Weiser - Frontiers in neuroendocrinology, 2014 - Elsevier
The hypothalamo–pituitary–adrenal (HPA) axis represents a complex neuroendocrine
feedback loop controlling the secretion of adrenal glucocorticoid hormones. Central to its …

Sex differences in vascular physiology and pathophysiology: estrogen and androgen signaling in health and disease

AC Boese, SC Kim, KJ Yin, JP Lee… - American Journal of …, 2017 - journals.physiology.org
Sex differences between women and men are often overlooked and underappreciated when
studying the cardiovascular system. It has been long assumed that men and women are …

Androgen insensitivity syndrome

IA Hughes, JD Davies, TI Bunch, V Pasterski… - The Lancet, 2012 - thelancet.com
Androgen insensitivity syndrome in its complete form is a disorder of hormone resistance
characterised by a female phenotype in an individual with an XY karyotype and testes …

Sex differences and sex steroids in lung health and disease

EA Townsend, VM Miller, YS Prakash - Endocrine reviews, 2012 - academic.oup.com
Sex differences in the biology of different organ systems and the influence of sex hormones
in modulating health and disease are increasingly relevant in clinical and research areas …

Sex hormones and their receptors regulate liver energy homeostasis

M Shen, H Shi - International journal of endocrinology, 2015 - Wiley Online Library
The liver is one of the most essential organs involved in the regulation of energy
homeostasis. Hepatic steatosis, a major manifestation of metabolic syndrome, is associated …

Exogenous testosterone rapidly increases aggressive behavior in dominant and impulsive men

JM Carré, SN Geniole, TL Ortiz, BM Bird, A Videto… - Biological …, 2017 - Elsevier
Background Although traditional wisdom suggests that baseline levels of testosterone (T)
promote aggressive behavior, decades of research have produced findings that have been …

Estrogen and androgen receptors: regulators of fuel homeostasis and emerging targets for diabetes and obesity

F Mauvais-Jarvis - Trends in Endocrinology & Metabolism, 2011 - cell.com
Because of increasing life expectancy, the contribution of age-related estrogen or androgen
deficiency to obesity and type 2 diabetes will become a new therapeutic challenge. This …