A guide to complement biology, pathology and therapeutic opportunity
DC Mastellos, G Hajishengallis… - Nature Reviews …, 2024 - nature.com
Complement has long been considered a key innate immune effector system that mediates
host defence and tissue homeostasis. Yet, growing evidence has illuminated a broader …
host defence and tissue homeostasis. Yet, growing evidence has illuminated a broader …
The state of complement in COVID-19
Hyperactivation of the complement and coagulation systems is recognized as part of the
clinical syndrome of COVID-19. Here we review systemic complement activation and local …
clinical syndrome of COVID-19. Here we review systemic complement activation and local …
Autocrine vitamin D signaling switches off pro-inflammatory programs of TH1 cells
The molecular mechanisms governing orderly shutdown and retraction of CD4+ type 1
helper T (TH1) cell responses remain poorly understood. Here we show that complement …
helper T (TH1) cell responses remain poorly understood. Here we show that complement …
Complosome—the intracellular complement system
The complement system is a recognized pillar of host defence against infection and noxious
self-derived antigens. Complement is traditionally known as a serum-effective system …
self-derived antigens. Complement is traditionally known as a serum-effective system …
Gut-licensed IFNγ+ NK cells drive LAMP1+TRAIL+ anti-inflammatory astrocytes
Astrocytes are glial cells that are abundant in the central nervous system (CNS) and that
have important homeostatic and disease-promoting functions. However, little is known about …
have important homeostatic and disease-promoting functions. However, little is known about …
Increased complement activation is a distinctive feature of severe SARS-CoV-2 infection
L Ma, SK Sahu, M Cano, V Kuppuswamy, J Bajwa… - Science …, 2021 - science.org
Complement activation has been implicated in the pathogenesis of severe SARS-CoV-2
infection. However, it remains to be determined whether increased complement activation is …
infection. However, it remains to be determined whether increased complement activation is …
Endothelial C3a receptor mediates vascular inflammation and blood-brain barrier permeability during aging
Dysfunction of immune and vascular systems has been implicated in aging and Alzheimer
disease; however, their interrelatedness remains poorly understood. The complement …
disease; however, their interrelatedness remains poorly understood. The complement …
Mitochondrial C5aR1 activity in macrophages controls IL-1β production underlying sterile inflammation
While serum-circulating complement destroys invading pathogens, intracellularly active
complement, termed the “complosome,” functions as a vital orchestrator of cell-metabolic …
complement, termed the “complosome,” functions as a vital orchestrator of cell-metabolic …
C5a-licensed phagocytes drive sterilizing immunity during systemic fungal infection
Systemic candidiasis is a common, high-mortality, nosocomial fungal infection.
Unexpectedly, it has emerged as a complication of anti-complement C5-targeted …
Unexpectedly, it has emerged as a complication of anti-complement C5-targeted …
Cell-autonomous regulation of complement C3 by factor H limits macrophage efferocytosis and exacerbates atherosclerosis
Complement factor H (CFH) negatively regulates consumption of complement component 3
(C3), thereby restricting complement activation. Genetic variants in CFH predispose to …
(C3), thereby restricting complement activation. Genetic variants in CFH predispose to …